Abstract Miniaturized extraction techniques are well established in analytical protocols following the guidelines of green chemistry. In spite of this, analytical chemistry researchers continue to look for alternatives and modifications that minimize or solve problems associated with the application of microextraction techniques. This manuscript goes over the most significant advances proposed from mid-2016 to the end of 2018. Thus, different possibilities are reported to minimize the major shortcoming of each modality of liquid-phase microextraction (LPME). The necessity of reducing extraction time and the toxicity of solvents used, and also enhancing the selectivity and precision of these methods has increased the possibilities and applications of LPME.

中文翻译：

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液相微萃取：2016 年 5 月至 2018 年 12 月更新

摘要 在遵循绿色化学指导方针的分析方案中，微型化提取技术得到了很好的确立。尽管如此，分析化学研究人员仍在继续寻找替代方法和改进方法，以最大限度地减少或解决与微萃取技术应用相关的问题。这份手稿回顾了从 2016 年年中到 2018 年底提出的最重要的进展。因此，报告了不同的可能性，以尽量减少每种液相微萃取 (LPME) 模式的主要缺点。减少提取时间和所用溶剂的毒性以及提高这些方法的选择性和精度的必要性增加了 LPME 的可能性和应用。