We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal IgG1/IgG3) and controls (1,321 for types; 751 for haplotypes). We selected types and haplotypes because their uncorrected frequencies differed significantly from controls in a previous adult IgGSD/common variable immunodeficiency cohort: A*24; B*14; B*35; B*40; B*49; B*50; B*58; B*62; A*01,B*08; A*02,B*44; A*02,B*60; A*03,B*07; A*03,B*14; A*03,B*44; A*31,B*40; and A*32,B*14. We used χ2 analysis (2 × 4 tables) to identify frequency differences across three subgroups and controls. If the null hypothesis was rejected (p < 0.05), we computed 2 × 2 χ2 tables to compare six combinations of subgroup and control frequencies [Bonferroni p < 0.0083 (< 0.05/6)]. Mean age was 48 ± 13 years; 82.2% were women. B*35 and B*40 frequencies were higher in subnormal IgG1 than subnormal IgG3 patients (0.1000 vs. 0.0248 and 0.0571 vs. 0.0083, respectively; p ≤ 0.0061). B*62 frequencies were lower in three IgGSD subgroups than controls (p < 0.0001, respectively). A*02, B*44 frequency was higher in subnormal IgG1/IgG3 patients than controls (0.1282 vs. 0.0632, respectively; p = 0.0024). A*02, B*60 frequency was lower in subnormal IgG3 patients than controls (0.0 vs. 0.0233, respectively; p = 0.0051). HLA-B*35 and -B*40 frequencies differ significantly between some IgGSD subgroups. B*62, A*02, B*44, and A*02, B*60 frequencies differ significantly between some IgGSD subgroups and controls.

中文翻译：

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IgG亚类缺陷亚组中的HLA-A和-B型和单倍型频率。

我们试图确定在患有IgG亚类缺乏症（IgGSD）的成年人亚组之间，HLA-A和-B型和单倍型频率是否不同。我们回顾性比较了269名无关成人IgGSD患者（70个亚正常IgG1； 121个亚正常IgG3； 78个亚正常IgG1 / IgG3）和对照组（1,321个类型； 751个单倍型）的三个亚组的类型和单倍型频率。我们选择类型和单倍型是因为它们的未校正频率与以前的成人IgGSD /常见可变免疫缺陷人群：A * 24；与对照组相比有显着差异。B * 14；B * 35；B * 40；B * 49；B * 50；B * 58；B * 62；A * 01，B * 08; A * 02，B * 44; A * 02，B * 60; A * 03，B * 07; A * 03，B * 14; A * 03，B * 44; A * 31，B * 40; 和A * 32，B * 14。我们使用χ2分析（2×4表）来确定三个亚组和对照组之间的频率差异。如果原假设被拒绝（p <0.05），我们计算了2×2χ2表，以比较子组频率和控制频率的六个组合[Bonferroni p <0.0083（<0.05 / 6）]。平均年龄为48±13岁；妇女占82.2％。低于正常水平IgG1的患者的B * 35和B * 40频率高于低于正常水平IgG3的患者（分别为0.1000对0.0248和0.0571对0.0083； p≤0.0061）。三个IgGSD亚组中的B * 62频率低于对照组（分别为p <0.0001）。亚正常IgG1 / IgG3患者的A * 02，B * 44频率高于对照组（分别为0.1282和0.0632； p = 0.0024）。亚正常IgG3患者的A * 02，B * 60频率低于对照组（分别为0.0和0.0233； p = 0.0051）。在某些IgGSD亚组之间，HLA-B * 35和-B * 40的频率明显不同。B * 62，A * 02，B * 44和A * 02，