The objective was to examine the discriminatory ability of electroencephalogram (EEG) delta power in neonates with hypoxic-ischemic encephalopathy (HIE) with well-defined outcomes. Prolonged continuous EEG recordings from term neonates with HIE during therapeutic hypothermia enrolled in a prospective observational study were examined. Adverse outcome was defined as death or severe brain injury by magnetic resonance imaging (MRI); favorable outcome was defined as normal or mild injury by MRI. Neonates were stratified by Sarnat grade of encephalopathy at admission. EEG was partitioned into 10-minute nonoverlapping artifact- and seizure-free epochs. Delta power was calculated and compared between the groups using receiver operating characteristic (ROC) analyses and Wilcoxon rank-sum tests. An area under the ROC curve >0.7 with P <.05 was considered a significant separation between groups. The favorable outcome group (n = 67) had higher delta power than the adverse outcome group (n = 28) across the majority of time periods from 9 to 90 hours of life. Delta power discriminated outcome groups for neonates with moderate encephalopathy (63 favorable and 14 adverse outcome) earlier in cooling (9-42 hours of life) than neonates with severe encephalopathy (21-42 hours of life). Outcome groups were differentiated after 81 hours of life in neonates with moderate and severe encephalopathy. Delta power can distinguish cooled HIE neonates with adverse outcome independently of the encephalopathy grade at presentation. Delta power may be a real-time continuous biomarker of evolving encephalopathy and brain injury/death in neonates with HIE.

中文翻译：

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新生儿缺氧缺血性脑病的连续脑电图 Delta Power 的预后价值。

目的是检查具有明确结果的缺氧缺血性脑病 (HIE) 新生儿的脑电图 (EEG) delta 功率的辨别能力。检查了在前瞻性观察研究中招募的治疗性低温期间患有 HIE 的足月新生儿的长时间连续 EEG 记录。磁共振成像（MRI）将不良结果定义为死亡或严重脑损伤；有利的结果被定义为 MRI 正常或轻度损伤。新生儿在入院时按脑病的 Sarnat 分级进行分层。脑电图被划分为 10 分钟不重叠的无伪影和无癫痫发作的时期。使用受试者工作特征 (ROC) 分析和 Wilcoxon 秩和检验计算和比较组间的 Delta 功率。ROC 曲线下面积 >0.7，P <。05 被认为是群体之间的重大分离。在 9 至 90 小时的大部分时间段内，有利结果组（n = 67）的 delta 功效高于不利结果组（n = 28）。Delta power 区分中度脑病新生儿（63 项有利结果和 14 项不利结果）的结果组比重度脑病新生儿（21-42 小时）更早冷却（9-42 小时）。在患有中度和重度脑病的新生儿中，在出生 81 小时后区分结果组。Delta power 可以独立于就诊时的脑病分级来区分具有不良结果的降温 HIE 新生儿。Delta power 可能是 HIE 新生儿发展性脑病和脑损伤/死亡的实时连续生物标志物。在 9 至 90 小时的大部分时间段内，有利结果组（n = 67）的 delta 功效高于不利结果组（n = 28）。Delta power 区分中度脑病新生儿（63 项有利结果和 14 项不利结果）的结果组比重度脑病新生儿（21-42 小时）更早冷却（9-42 小时）。在患有中度和重度脑病的新生儿中，在出生 81 小时后区分结果组。Delta power 可以独立于就诊时的脑病分级来区分具有不良结果的降温 HIE 新生儿。Delta power 可能是 HIE 新生儿发展性脑病和脑损伤/死亡的实时连续生物标志物。在 9 至 90 小时的大部分时间段内，有利结果组（n = 67）的 delta 功效高于不利结果组（n = 28）。Delta power 区分中度脑病新生儿（63 项有利结果和 14 项不利结果）的结果组比重度脑病新生儿（21-42 小时）更早冷却（9-42 小时）。在患有中度和重度脑病的新生儿中，在出生 81 小时后区分结果组。Delta power 可以独立于就诊时的脑病分级来区分具有不良结果的降温 HIE 新生儿。Delta power 可能是 HIE 新生儿发展性脑病和脑损伤/死亡的实时连续生物标志物。