Drug Discovery Today ( IF 7.4 ) Pub Date : 2020-04-20 , DOI: 10.1016/j.drudis.2020.04.010 Thomas J Manning 1 , Jenu Thomas-Richardson 1 , Matthew Cowan 1 , Torien Beard 1
This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.
中文翻译:
蒸发,生物活性制剂和海洋天然产物:关于抗病毒药的不同观点。
本文研究了抗病毒药的三个方面,例如羟氯喹,氯喹和瑞姆斯韦,因为它们可能与诸如COVID-19的病毒感染的治疗有关:(i)利用汽化来递送抗病毒剂,大部分具有轻度抗病毒功效的成分;(ii)与单一分子相反的海洋天然产物提取物作为抗病毒剂的应用;(iii)一种反直觉的配方方法,该方法部分基于提供多种生物,这些生物可分为三类:病毒加速复制的基础;感染细胞增强免疫反应的能源;以及拮抗病毒或对病毒提供毒性的物种。