Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas. It has shown a poor prognosis and a rising incidence in the developed world. Other pathologies associated with this tissue include pancreatitis, a risk condition for pancreatic cancer. The onset of both pancreatitis and pancreatic cancer follows a common pattern: exocrine pancreatic acinar cells undergo a transdifferentiation to duct cells that triggers a 3D restructuration of the pancreatic tissue. However, the exact mechanism underlying this process remains partially undefined. Further understanding the cellular events leading to PDAC could open new avenues in the development of novel therapeutic approaches. Since current 2D cell culture models fail to mimic the tridimensional complexity of the pancreatic tissue, new in vitro models are urgently needed. Here, we generated 3D pancreatic cell spheroid arrays using laser-assisted bioprinting and characterized their phenotypic evolution o...

中文翻译：

---

外分泌胰腺球状体模型的激光辅助3D生物打印，用于癌症研究。

胰腺导管腺癌（PDAC）是胰腺最常见的恶性肿瘤。在发达国家，该病预后差，发病率上升。与该组织相关的其他病理包括胰腺炎，这是胰腺癌的危险状况。胰腺炎和胰腺癌的发作均遵循一种常见模式：外分泌胰腺腺泡细胞发生向导管细胞的转分化，从而触发胰腺组织的3D重组。但是，此过程背后的确切机制仍然部分不确定。进一步了解导致PDAC的细胞事件可为新型治疗方法的开发开辟新途径。由于当前的2D细胞培养模型无法模仿胰腺组织的三维复杂性，因此迫切需要新的体外模型。这里，