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Cytotoxic effects of vitamins K1, K2, and K3 against human T lymphoblastoid leukemia cells through apoptosis induction and cell cycle arrest.
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2020-04-18 , DOI: 10.1111/cbdd.13696 Wencheng Xu 1, 2 , Hongguang Wu 3 , Shuhe Chen 1, 2 , Xiaoqin Wang 2, 4 , Sachiko Tanaka 3 , Kentaro Sugiyama 3 , Haruki Yamada 3 , Toshihiko Hirano 3
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2020-04-18 , DOI: 10.1111/cbdd.13696 Wencheng Xu 1, 2 , Hongguang Wu 3 , Shuhe Chen 1, 2 , Xiaoqin Wang 2, 4 , Sachiko Tanaka 3 , Kentaro Sugiyama 3 , Haruki Yamada 3 , Toshihiko Hirano 3
Affiliation
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The present study was undertaken to evaluate cytotoxic effects of vitamin K1 (phylloquinone), vitamin K2 (menaquinones), and vitamin K3 (menadione) against human T lymphoblastoid leukemia cells, Jurkat T cells, MOLT‐4 cells, and P‐glycoprotein‐expressing multidrug‐resistant MOLT‐4/DNR cells. Vitamins K2 and K3, but not vitamin K1, reduced viabilities of Jurkat, MOLT‐4, and MOLT‐4/DNR cells. The influence potency of vitamin K3 was larger than that of vitamin K2 in all of the three cell lines. MOLT‐4/DNR cells seemed to be more sensitive toward the effects of vitamins K2 and K3. The cytotoxicity of vitamins K2 and K3 on these leukemia cells seems to be related to apoptosis induction and cell cycle arrest. Vitamin K2 and K3 treatment induced cleavage of PARP obviously. Moreover, vitamins K2 and K3 specifically down‐regulated the expressions of cyclin A2 in all of the three cell lines. However, the effects of vitamins K2 and K3 on the cell cycle profiling in Jurkat, MOLT‐4, and MOLT‐4/DNR cells varied with the cell type. Vitamins K2 and K3 also decreased the viability of mitogen‐activated human peripheral blood mononuclear cells. Our observations suggest that vitamins K2 and K3 have bilateral cytotoxic effects on activated human peripheral lymphocytes and the human leukemic T cells.
中文翻译：
维生素K1，K2和K3通过凋亡诱导和细胞周期阻滞对人T淋巴细胞母细胞白血病细胞的细胞毒性作用。
本研究旨在评估维生素K1（叶绿醌），维生素K2（甲萘醌）和维生素K3（甲萘醌）对人T淋巴母细胞白血病细胞，Jurkat T细胞，MOLT-4细胞和P-糖蛋白表达的细胞毒性作用多药耐药的MOLT-4 / DNR细胞。维生素K2和K3，而不是维生素K1，降低了Jurkat，MOLT-4和MOLT-4 / DNR细胞的活力。在所有三个细胞系中，维生素K3的影响力均大于维生素K2。MOLT-4 / DNR细胞似乎对维生素K2和K3的影响更为敏感。维生素K2和K3对这些白血病细胞的细胞毒性似乎与凋亡诱导和细胞周期停滞有关。维生素K2和K3处理可明显诱导PARP裂解。此外，维生素K2和K3特异性下调了所有三个细胞系中细胞周期蛋白A2的表达。但是，维生素K2和K3对Jurkat，MOLT-4和MOLT-4 / DNR细胞的细胞周期分布的影响随细胞类型而异。维生素K2和K3还降低了促分裂原活化的人外周血单核细胞的活力。我们的观察结果表明，维生素K2和K3对活化的人外周血淋巴细胞和人白血病T细胞具有双边细胞毒作用。
更新日期：2020-04-18
中文翻译：
维生素K1，K2和K3通过凋亡诱导和细胞周期阻滞对人T淋巴细胞母细胞白血病细胞的细胞毒性作用。
本研究旨在评估维生素K1（叶绿醌），维生素K2（甲萘醌）和维生素K3（甲萘醌）对人T淋巴母细胞白血病细胞，Jurkat T细胞，MOLT-4细胞和P-糖蛋白表达的细胞毒性作用多药耐药的MOLT-4 / DNR细胞。维生素K2和K3，而不是维生素K1，降低了Jurkat，MOLT-4和MOLT-4 / DNR细胞的活力。在所有三个细胞系中，维生素K3的影响力均大于维生素K2。MOLT-4 / DNR细胞似乎对维生素K2和K3的影响更为敏感。维生素K2和K3对这些白血病细胞的细胞毒性似乎与凋亡诱导和细胞周期停滞有关。维生素K2和K3处理可明显诱导PARP裂解。此外，维生素K2和K3特异性下调了所有三个细胞系中细胞周期蛋白A2的表达。但是，维生素K2和K3对Jurkat，MOLT-4和MOLT-4 / DNR细胞的细胞周期分布的影响随细胞类型而异。维生素K2和K3还降低了促分裂原活化的人外周血单核细胞的活力。我们的观察结果表明，维生素K2和K3对活化的人外周血淋巴细胞和人白血病T细胞具有双边细胞毒作用。
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