Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic inflammation and oxidative stress are some examples. The downstream effects of SIRT1 activity have been thoroughly explored, and their research is still in expanse. SIRT1 activation has been shown to regulate pathways with beneficiary effects on 1) ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-II diabetes; 2) chronic inflammatory processes such as arthritis, atherosclerosis and emphysema, 3) DNA damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers. This knowledge intensified the interest in uncovering the mechanisms regulating the expression and activity of SIRT1. This review focuses on the upstream regulatory mechanisms controlling SIRT1, and, how this knowledge could potentially contribute to the development of therapeutic interventions.

中文翻译：

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SIRT1 衰老和肥胖调节。

衰老和肥胖有共同的特征：葡萄糖和脂质代谢改变、慢性炎症和氧化应激就是一些例子。SIRT1活性的下游效应已经得到深入探索，他们的研究仍在进行中。SIRT1 激活已被证明可以调节通路，对 1) 衰老和肥胖相关的代谢紊乱如代谢综合征、胰岛素抵抗和 II 型糖尿病具有有益作用；2) 慢性炎症过程，如关节炎、动脉粥样硬化和肺气肿，3) DNA 损伤和氧化应激对神经退行性疾病、心血管健康和某些癌症的影响。这些知识增强了人们对揭示调节 SIRT1 表达和活性的机制的兴趣。本综述重点关注控制 SIRT1 的上游监管机制，以及，