The complexity and the mechanistic role of microbial communities at mucosal surfaces are only now beginning to be understood. Their impact on host metabolism, development, and immune responses to infectious and inert stimuli may be centrally linked to the metabolic functions of these communities within the established microbiome. The structure and function of microbial communities are influenced both early and throughout life by many environmental factors, exposures, diet, and disease. Understanding how the microbiome influences the host during health is likely just as important as understanding how it influences asthmatic disease predisposition and severity.

中文翻译：

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哮喘发病机制和表型中的微生物群-免疫相互作用。

现在才开始了解粘膜表面微生物群落的复杂性和机制作用。它们对宿主代谢、发育和对感染性和惰性刺激的免疫反应的影响可能与已建立的微生物组内这些群落的代谢功能密切相关。微生物群落的结构和功能受到许多环境因素、暴露、饮食和疾病的早期和整个生命的影响。了解微生物组在健康期间如何影响宿主可能与了解它如何影响哮喘疾病的易感性和严重程度一样重要。