In this trends article, we review seminal and recent studies using static and magic-angle spinning solid-state NMR to study the structure of nanoparticles and ligands attached to nanoparticles. Solid-state NMR techniques including one-dimensional multinuclear NMR, cross-polarization, techniques for measuring dipolar coupling and internuclear distances, and multidimensional NMR have provided insight into the core-shell structure of nanoparticles as well as the structure of ligands on the nanoparticle surface. Hyperpolarization techniques, in particular solid-state dynamic nuclear polarization (DNP), have enabled detailed studies of nanoparticle core-shell structure and surface chemistry, by allowing unprecedented levels of sensitivity to be achieved. The high signal-to-noise afforded by DNP has allowed homonuclear and heteronuclear correlation experiments involving nuclei with low natural abundance to be performed in reasonable experimental times, which previously would not have been possible. The use of DNP to study nanoparticles and their applications will be a fruitful area of study in the coming years as well.

在这篇趋势文章中，我们回顾了使用静态和魔术角旋转固态NMR研究纳米粒子和与纳米粒子相连的配体的结构的开创性和最新研究。固态NMR技术（包括一维多核NMR，交叉极化，测量偶极耦合和核间距离的技术以及多维NMR）提供了对纳米颗粒核壳结构以及纳米颗粒表面配体结构的了解。 。超极化技术，尤其是固态动态核极化（DNP），通过实现前所未有的灵敏度水平，已经能够对纳米颗粒核-壳结构和表面化学进行详细研究。DNP提供的高信噪比使得同核和异核相关实验能够在合理的实验时间内进行，而核​​实验的天然丰度低，这在以前是不可能的。在未来几年中，使用DNP研究纳米颗粒及其应用也将是一个富有成果的研究领域。