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High-Grade Surface Osteosarcoma: Clinical Features and Oncologic Outcome.
Journal of Bone Oncology ( IF 3.1 ) Pub Date : 2020-04-18 , DOI: 10.1016/j.jbo.2020.100288
Zhiping Deng 1 , Zhen Huang 1 , Yi Ding 2 , Yongbin Su 3 , Chung Ming Chan 4 , Xiaohui Niu 1
Affiliation  

Background

High-grade surface osteosarcoma is an extremely rare subtype of osteosarcoma. The treatment outcome for this tumor varies in different centers.

Methods

This was a retrospective study of high-grade surface osteosarcoma; clinical, radiological, and histological materials were reviewed.

Results

We studied 23 patients (16 males, seven females); median age was 24 years old. All the tumors involved the lower limb, located at the diaphysis in 11 patients and at the metaphysis in 12 patients. Even though the majority of tumors were located at the surface of the bone, the medullary canal was involved in 10 patients. The microscopic findings were indistinguishable from conventional central osteosarcoma. All the patients were treated with a combination of surgery and systemic chemotherapy. Follow-up data were completed in 20 patients; follow-up duration ranged from 27 months to 182 months or until the patient died of the disease (5–104 months). Of the 20 patients, 12 died of the disease, and eight patients were alive at the time of the last follow-up. The 5-year overall survival rate was 37.6%.

Conclusions

Our study revealed that the treatment outcome for this tumor shows a poor survival rate.



中文翻译:

高级表面骨肉瘤:临床特征和肿瘤学结果。

背景

高级别表面骨肉瘤是一种极为罕见的骨肉瘤亚型。这种肿瘤的治疗结果在不同的中心有所不同。

方法

这是一项高级别表面骨肉瘤的回顾性研究;审查了临床、放射学和组织学材料。

结果

我们研究了 23 名患者(16 名男性,7 名女性);中位年龄为 24 岁。肿瘤均累及下肢,11例位于骨干,12例位于干骺端。尽管大多数肿瘤位于骨表面,但有 10 名患者累及髓管。显微镜下的发现与传统的中央骨肉瘤没有区别。所有患者均接受手术和全身化疗相结合的治疗。20例患者完成随访资料;随访时间从 27 个月到 182 个月不等或直到患者死于疾病(5-104 个月)。在 20 名患者中,12 人死于该病,8 名患者在最后一次随访时存活。5年总生存率为37.6%。

结论

我们的研究表明,这种肿瘤的治疗结果显示存活率很低。

更新日期:2020-04-18
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