BACKGROUND CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren's syndrome (pSS). However, whether CD72 is involved in the process remains unknown. This study aimed to observe the possible role of CD72 in the pathogenesis of pSS. RESULTS A total of 60 cases who fulfilled the American-European Consensus Group (AECG) criteria for the diagnosis of pSS and 61 gender and age-matched healthy controls were recruited in this study. The percentage of CD72+ B cells was 85.31 ± 8.37% in pSS patients and 76.91 ± 8.50% in healthy controls(p < 0.001). The percentage of CD72+ B cells was correlated to serum IgG levels in patients [β = 0.018(0.001-0.036), p = 0.034]. The level of serum soluble CD72 was significantly higher in pSS patients than the one in healthy controls (0.41 (0.29) vs 0.07 (0.08) ng/mL, p < 0.001). CONCLUSIONS The percentage of CD72+ B cells was upregulated in pSS patients and was correlated to the serum IgG level, which revealed the hyperactivity of B cells in this disease. The serum soluble CD72 level was also increased in pSS patients. These results indicated a potential role of CD72 in the pathogenesis of pSS.

中文翻译：

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在原发性干燥综合征中，CD72在B细胞上表达和增加可溶性CD72的调节作用。

背景技术据报道，CD72是B细胞受体（BCR）的共同受体，在几种免疫疾病中对B细胞功能具有正作用和负作用。B细胞在原发性干燥综合征（pSS）的发病机理中起重要作用。但是，CD72是否参与该过程仍然未知。这项研究旨在观察CD72在pSS发病机理中的可能作用。结果本研究共招募了60例符合p-SS诊断的美国-欧洲共识小组（AECG）标准的患者，以及61名性别和年龄匹配的健康对照者。pSS患者的CD72 + B细胞百分比为85.31±8.37％，健康对照者为76.91±8.50％（p <0.001）。患者中CD72 + B细胞的百分比与血清IgG水平相关[β= 0.018（0.001-0.036），p = 0.034]。pSS患者的血清可溶性CD72水平明显高于健康对照者（0.41（0.29）vs 0.07（0.08）ng / mL，p <0.001）。结论pSS患者CD72 + B细胞的百分比上调，并且与血清IgG水平相关，这揭示了该疾病中B细胞的过度活跃。pSS患者的血清可溶性CD72水平也升高。这些结果表明CD72在pSS的发病机理中的潜在作用。pSS患者的血清可溶性CD72水平也升高。这些结果表明CD72在pSS的发病机理中的潜在作用。pSS患者的血清可溶性CD72水平也升高。这些结果表明CD72在pSS的发病机理中的潜在作用。