Peptides have attracted great interests due to their potential for versatile application in preparation of drug carriers because of their specific targeting capability to desired tissues and bioresponsiveness toward various biological molecules such as enzymes for selective cleavage or bio-responsive folding into specific conformation. Therefore, the introduction of peptides as a gatekeeper on the surface would provide MSNs with triggered release property of guest molecules in response to a variety of biological stimuli including specific enzymes at specific target sites. In this review, we discuss the recent progress of peptide gatekeepers on MSNs by classification of the stimuli for triggering the release of payloads from the mesopore. We also describe the on-off gatekeepers by employing the motif of conformational transformation of peptides in response to external stimuli. The myriad biological functions of peptides by interaction with biomolecules, cells and organs endow the peptide gatekeepers on MSNs with great potential to construct smart nanocarriers.

中文翻译：

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用于智能纳米载体的刺激响应性肽网守

肽由于其在所需载体中的特异性靶向能力以及对各种生物分子（例如用于选择性切割或生物反应性折叠成特定构象的酶）的生物反应性，因其在制备药物载体中的广泛应用潜力而备受关注。因此，在表面上引入肽作为守门员将为MSN提供响应于多种生物刺激（包括特定目标部位的特定酶）的客体分子触发释放特性。在这篇综述中，我们通过分类触发从中孔释放有效载荷的刺激，讨论了MSNs上的肽关守的最新进展。我们还通过响应外部刺激，采用肽的构象转化基序来描述开关门将。通过与生物分子，细胞和器官的相互作用，肽具有无数的生物学功能，这赋予了MSNs上的肽守门员巨大的潜力来构建智能纳米载体。