The aim of the study was to evaluate haematological responses in Red Sokoto goats (RSGs) administered with L-glutamine during the hot-dry season. Experimental animals included 28 clinically healthy RSGs divided into treated group (n = 14); each administered L-glutamine at 0.2 g/kg body weight, dissolved in 10 mL distilled water, and control group (n = 14); each administered 10 mL distilled water, per os once daily for 21 days. The ambient temperature and relative humidity recorded daily for 4 weeks were used to calculate the temperature-humidity index. Three millilitres of blood sample was collected from each goat by jugular venipuncture for haematology, while rectal temperature (RT), heart rate (HR) and respiratory rate (RR) were also measured once weekly at weeks 0 (before), 1, 2, 3 (during) and 4 (after L-glutamine administration). The haematological, RT, HR and RR data obtained weekly were analysed using repeated-measures one-way ANOVA, followed by Tukey's post-hoc test to evaluate differences between periods, and between treated and control groups. The PCV, haemoglobin concentration and RBC count were higher (P < 0.05) in the treated group compared to the control group during the period of L-glutamine administration. These differences were sustained till week 4. Beginning from week 1 of the study, the total leucocyte count in treated group (10.10 ± 0.25 × 103/μL) was higher (P < 0.05) than the count in control group (7.23 ± 0.41 × 103/μL), this trend was also maintained throughout the study. The neutrophil:lymphocyte ratio during weeks 3 and 4 of the experiment was lower (P < 0.05) in the treated compared to the control group. RT was lower (P < 0.05) in treated group than the control group. In conclusion, L-glutamine administration ameliorated the adverse effects of heat stress on the haematological parameters in RSGs during the hot-dry season.

中文翻译：

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L-谷氨酰胺对热应激红索科托山羊血液学参数的改善作用

该研究的目的是评估在干热季节服用 L-谷氨酰胺的红索科托山羊 (RSG) 的血液学反应。实验动物包括 28 只临床健康的 RSG，分为治疗组（n = 14）；分别以 0.2 g/kg 体重服用 L-谷氨酰胺，溶于 10 mL 蒸馏水中，对照组（n = 14）；每次给药 10 mL 蒸馏水，每天口服一次，共 21 天。使用连续 4 周每天记录的环境温度和相对湿度来计算温湿度指数。通过颈静脉穿刺从每只山羊身上采集 3 毫升血样用于血液学，同时还在第 0 周（之前）、第 1、第 2 周和每周一次测量直肠温度（RT）、心率（HR）和呼吸频率（RR）。 3（期间）和 4（L-谷氨酰胺给药后）。每周获得的血液学、RT、HR 和 RR 数据使用重复测量单向方差分析进行分析，然后使用 Tukey 事后检验来评估不同时期之间以及治疗组和对照组之间的差异。在L-谷氨酰胺给药期间，与对照组相比，治疗组的PCV、血红蛋白浓度和RBC计数较高（P < 0.05）。这些差异一直持续到第 4 周。从研究的第 1 周开始，治疗组的总白细胞计数 (10.10 ± 0.25 × 103/μL) 高于对照组 (P < 0.05)（7.23 ± 0.41 × 103/μL），在整个研究过程中也保持了这种趋势。与对照组相比，治疗组在实验的第 3 周和第 4 周期间的中性粒细胞:淋巴细胞比率较低 (P < 0.05)。RT 较低（P < 0。05) 治疗组优于对照组。总之，L-谷氨酰胺给药改善了热应激对干热季节 RSG 血液学参数的不利影响。