CONTEXT Hyperthermia is known to be beneficial to patients affected by various diseases. Brain Derived Neurotrophic Factor (BDNF) is a marker of neuroplasticity usually increased as response to acute exposure to human body stressors. Little is known about BDNF changes after repeated exposure to hyperthermia. OBJECTIVE To investigate the effect of a repeated hyperthermia exposure programme (HTC) on serum BDNF in healthy humans. DESIGN, SETTING, PARTICIPANTS Randomized, single-blind, controlled trial in healthy humans conducted at Sechenov University Physiology Laboratory between December 2016 and November 2018. The treatment period was 10 weeks. Researchers analysing serum BDNF and questionnaires data were blinded to participants allocation. PARTICIPANTS Were 34 healthy male (age 20.2 ± 1.6 years). INTERVENTION Repeated Hyperthermia exposure programme, HTC, versus Light Intermittent Exercise, LIE, programme as control (10 weeks). MAIN OUTCOME MEASURE Change in BDNF from baseline to final visit three days after treatment completion. RESULTS 25 participants were analyzed. One participant withdrew before signing the informed consent and 8 participants (n = 3 in HTC and n = 5 in LIE) could not undertake the first assessment and were excluded. Mean change in BDNF was higher in HTC group vs LIE after both time points (after 12 and after 24 sessions). After 24 sessions BDNF was 30170 (SD 5268) pg/ml in HTC group a value that was significantly higher than 24104 (SD 2876) pg/ml measured in LIE group. BDNF concentrations were significantly higher than baseline values in HTC group only, 30170 (SD 5268) vs 26710 (SD 5437) pg/ml. CONCLUSION A 10-week programme consisting of repeated exposure to hyperthermia resulted in a significantly higher increase of circulating BDNF compared to a programme consisting of intermittent light intensity exercise.

中文翻译：

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反复热疗会增加循环脑源性神经营养因子水平，这与改善生活质量和减少焦虑有关：一项随机对照试验。

背景 众所周知，热疗对受各种疾病影响的患者有益。脑源性神经营养因子 (BDNF) 是神经可塑性的标志，通常随着对人体压力源的急性暴露做出反应而增加。对反复接触高温后 BDNF 的变化知之甚少。目的 研究重复热疗暴露程序 (HTC) 对健康人血清 BDNF 的影响。设计、设置、参与者 2016 年 12 月至 2018 年 11 月在谢切诺夫大学生理学实验室进行的健康人随机、单盲、对照试验。治疗期为 10 周。分析血清 BDNF 和问卷数据的研究人员对参与者分配不知情。参与者是 34 名健康男性（年龄 20.2 ± 1.6 岁）。干预 重复热疗暴露计划，HTC，与轻度间歇性运动，LIE，计划作为对照（10 周）。主要结果测量 治疗完成后三天 BDNF 从基线到最终访问的变化。结果 分析了 25 名参与者。一名参与者在签署知情同意书之前退出，8 名参与者（HTC 中 n = 3 和 LIE 中 n = 5）无法进行第一次评估并被排除在外。在两个时间点后（12 次和 24 次后），HTC 组的 BDNF 平均变化高于 LIE。24 个疗程后，HTC 组的 BDNF 为 30170 (SD 5268) pg/ml，该值显着高于 LIE 组中测量的 24104 (SD 2876) pg/ml。BDNF 浓度仅显着高于 HTC 组的基线值，30170 (SD 5268) 比 26710 (SD 5437) pg/ml。