The objective of traditional Chinese medicine (TCM) combination theory is to “reduce toxicity and increase efficiency”, especially to solve the liver toxicity of many TCMs. Fructus Meliae Toosendan (CLZ)–Fructus Foeniculi (XHX) is a typical traditional Chinese herb pair that decreases the toxicity and increases the efficiency of the herbs. Fructus Meliae Toosendan (CLZ, cold‐natured) has significant liver toxicity. However, it has been widely used in combination with Fructus Foeniculi (XHX, hot‐natured) for thousands of years in TCM, in which form it shows no hepatotoxicity, indicating that the combined use of XHX and CLZ can reduce the hepatotoxicity of CLZ. Herb–herb interactions could affect herb pharmacokinetics and in vivo efficacy. The herb–herb interactions between CLZ and XHX are still unknown.

中文翻译：

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HPLC-MS / MS和GC-MS / MS测定大鼠血浆中苦参子和太子参中的太生丹宁和反式茴香脑及其潜在的药草相互作用。

中药组合理论的目的是“降低毒性，提高效率”，尤其是解决许多中药的肝脏毒性。Mel子五味子（CLZ）– Fo子（XHX）是典型的中药对，可降低毒性并提高药效。Mel子五味子（CLZ，自然界）具有明显的肝毒性。但是，它与中药枸杞（XHX，热性质）组合使用已有数千年的历史，其形式没有肝毒性，表明XHX和CLZ的组合使用可以降低CLZ的肝毒性。草药之间的相互作用可能会影响草药的药代动力学和体内功效。CLZ和XHX之间的药草相互作用仍然未知。