Abstract

Melatonin (N-acetyl-5-methoxy-tryptamine) is an effective antioxidant and free radical scavenger, that has important biological effects in multiple cell types and species. Melatonin research in muscle has recently gained attention, mainly focused on its role in cells or tissue repair and regeneration after injury, due to its powerful biological functions, including its antioxidant, anti-inflammation, anti-tumor and anti-cancer, circadian rhythm, and anti-apoptotic effects. However, the effect of melatonin in regulating muscle development has not been systematically summarized. In this review, we outline the latest research on the involvement of melatonin in the regulation of muscle development and regeneration in order to better understand its underlying molecular mechanisms and potential applications.

中文翻译：

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褪黑激素在骨骼肌中的调节作用

摘要

褪黑激素（N-乙酰-5-甲氧基-色胺）是一种有效的抗氧化剂和自由基清除剂，在多种细胞类型和物种中具有重要的生物学作用。肌肉中的褪黑激素研究最近受到关注，主要集中在其在细胞或组织损伤后修复和再生中的作用，由于其强大的生物学功能，包括抗氧化、抗炎、抗肿瘤和抗癌、昼夜节律、和抗凋亡作用。然而，尚未系统地总结褪黑激素在调节肌肉发育方面的作用。在这篇综述中，我们概述了关于褪黑激素参与肌肉发育和再生调节的最新研究，以更好地了解其潜在的分子机制和潜在应用。