Sulfamethazine (SM2) is one of the sulfonamide antibiotics that is frequently detected in aquatic environment. Given the complex structure of SM2 and its potential threat to the environment, it is necessary to determine the degradation behavior of high-concentration SM2. The mechanisms of community structure and diversity of activated sludge were analyzed. A novel SM2-degrading strain YL1 was isolated which can degrade SM2 with high concentration of 100 mg L⁻¹. Strain YL1 was identified as Paenarthrobacter ureafaciens and there was also a significant increase in the genus during acclimation. Additional SM2 metabolic mechanisms and genomic information of YL1 were analyzed for further research. The succession of the community structure also investigated the effect of SM2 on the activated sludge. This result not only advances the current understanding of microbial ecology in activated sludge, but also has practical implications for the design and operation of the environmental bioprocesses for treatment of antimicrobial-bearing waste streams.

磺胺二甲嘧啶（SM2）是在水生环境中经常检测到的磺胺类抗生素之一。考虑到SM2的复杂结构及其对环境的潜在威胁，有必要确定高浓度SM2的降解行为。分析了活性污泥的群落结构和多样性机制。分离出新的SM2降解菌株YL1，该菌株可以以100 mg L ^-1的高浓度降解SM2 。菌株YL1被鉴定为脲原芽孢杆菌在驯化过程中属也显着增加。分析了其他SM2代谢机制和YL1的基因组信息，以进一步研究。群落结构的演替也研究了SM2对活性污泥的影响。该结果不仅提高了对活性污泥中微生物生态学的当前理解，而且对处理含微生物废物流的环境生物过程的设计和操作具有实际意义。