Dirofilaria immitis is a parasitic filarial nematode responsible for heartworm disease in domestic as well as wild canines and felines and pulmonary or cutaneous infections in humans. This systematic review and meta-analysis aimed to evaluate the status of D. immitis in dogs based on available literature. Four English language databases (ISI Web of Science, Scopus, PubMed and Science Direct) containing data on D. immitis prevalence in dogs were thoroughly searched resulting in the inclusion of 193 studies. The findings revealed that the pooled and weighted prevalence of D. immitis infection in dog population based on published papers throughout the world was 10.91% (95% CI=10.18-11.65). In addition, subgroup analysis based on meta-regression revealed that a significant difference between the pooled and weighted prevalence of D. immitis in dogs and country (β =0.14, P=0.049). Given the relatively high prevalence of D. immitis infection in dogs and its adverse effects, it is suggested that to perform more research on the prevention and control of dirofilariasis infection in dogs worldwide.

中文翻译：

---

狗的滴虫丝虫炎的全球状况：基于发表的文章的系统评价和荟萃分析。

Dirofilaria炎性线虫是一种寄生的丝虫线虫，负责家中以及野生犬和猫的心丝虫病，以及人类的肺部或皮肤感染。这项系统的回顾和荟萃分析旨在根据现有文献评估狗中D. immitis的状况。彻底搜索了四个英语语言数据库（ISI Web of Science，Scopus，PubMed和Science Direct），其中包含有关犬D.炎性流行率的数据，从而纳入了193项研究。研究结果表明，根据全世界已发表的论文，犬类中D. immitis感染的合并患病率为加权平均（10.91％）（95％CI = 10.18-11.65）。此外，基于元回归的亚组分析显示，D的合并患病率和加权患病率之间存在显着差异。狗和国家的炎症（β= 0.14，P = 0.049）。鉴于狗中D. immitis感染的患病率较高及其不良影响，建议在全球范围内开展更多有关预防和控制狗丝虫病感染的研究。