Background

Chronic spontaneous urticaria (CSU) is a disease that seriously disturbs the quality of life of the patient. Currently there is no prognostic marker of the disease. Our aim in this study was to determine possible prognostic markers of CSU in children.

Method

All patients younger than 18 years of age who were followed by the Pediatric Immunology and Allergy Clinic of Diyarbakir Children’s Hospital with a diagnosis of CSU between June 2017 and February 2019 were included in the study. Clinical and laboratory findings were compared between the symptomatic patient group and the patient group that remained in remission for at least three months without use of medication.

Results

Of the 52 cases included in the study, 32 (61.5%) were male. Mean age at time of diagnosis was 9.4 ± 4.4 years. Twenty-four cases (46.2%) went into remission. Young age at the time of diagnosis and being in the initial months of the disease were found to be associated with good prognosis (p < 0.05). Among laboratory results, elevation in absolute neutrophil count and neutrophil/lymphocyte ratio (NLR) were found to be associated with poor prognosis (p < 0.05). NLR was positively correlated with disease duration (p < 0.05).

Conclusion

For childhood CSU, younger age and initial months of the disease are good prognostic indicators, while only neutrophil/lymphocyte count can be used as a remission marker.

中文翻译：

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中性粒细胞-淋巴细胞比率：可能是慢性自发性荨麻疹患儿缓解的标志。

背景

慢性自发性荨麻疹（CSU）是一种严重干扰患者生活质量的疾病。目前尚无该疾病的预后指标。我们在这项研究中的目的是确定儿童CSU的可能预后指标。

方法

该研究纳入了所有年龄在18岁以下的患者，并于2017年6月至2019年2月之间接受了Diyarbakir儿童医院的儿科免疫学和过敏诊所的诊断为CSU的患者。比较有症状患者组和在不使用药物的情况下至少缓解三个月的患者组的临床和实验室检查结果。

结果

该研究包括的52例病例中，有32例（61.5％）是男性。诊断时的平均年龄为9.4±4.4岁。有24例（46.2％）缓解。在诊断时和在疾病的最初几个月中发现年轻年龄与良好的预后相关（p <0.05）。在实验室结果中，发现嗜中性白血球绝对计数和嗜中性白血球/淋巴细胞比率（NLR）升高与预后不良有关（p <0.05）。NLR与疾病持续时间呈正相关（p <0.05）。

结论

对于儿童CSU，较年轻和疾病的最初几个月是良好的预后指标，而仅嗜中性粒细胞/淋巴细胞计数可以用作缓解指标。