H2O2 Screening from Saliva of Gum Diseased‐patient through CN‐dot Wrapped Cu2O Nano‐frogspawns Ionic Liquid Nanocomposite,Electroanalysis

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H2O2 Screening from Saliva of Gum Diseased‐patient through CN‐dot Wrapped Cu2O Nano‐frogspawns Ionic Liquid Nanocomposite
Electroanalysis ( IF 2.7 ) Pub Date : 2020-03-22 , DOI: 10.1002/elan.202000047
Khizar Hayat ₁ , Mahmood Hassan Akhtar ₂ , Awais Siddique Saleemi ₃ , Hafiz Badaruddin Ahmad ₁ , Naeem Akhtar ₂

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Herein, we report the development of a robust, sensitive, and selective non‐enzymatic electrochemical sensor for the detection of hydrogen peroxide (H₂O₂). The novel BA modified CN‐dot wrapped Cu₂O‐nano‐frogspawn (FS@CN‐dot) sensor probe demonstrated a catalytic property towards H₂O₂ that allowed the highly sensitive electrochemical detection at a low reduction potential. The as prepared CN‐dot wrapped Cu₂O hetero‐structured nanocomposite was analyzed using surface analysis methods to confirm the morphology, crystallinity, and oxidation states of various constituents and dopant elements. Further, the morphological analysis of the Cu₂O nanoparticles revealed that the Cu₂O retains frogspawns‐liked structure. Under the optimized experimental conditions, the sensor showed a wide dynamic range of H₂O₂ from 0.5 μM to 9 mM with a detection limit (LD) of 1.2±0.1 nM. The designed sensing probe showed good stability, high sensitivity, and selectivity even in the presence of potential interfering molecules. To check the reliability of the fabricated sensor in biomedical applications, the proposed sensing probe was successfully applied to monitor H₂O₂ in saliva of a gum‐diseased patient. To the best of our knowledge, this report is the first of its kind not only because of its novel construction style in terms of CN source, but also in terms of real sample applicability as well.

中文翻译：

通过CN点包裹Cu2O纳米蛙卵离子液体纳米复合材料从口香糖病患者唾液中筛选H2O2

在此，我们报告了一种用于检测过氧化氢（H ₂ O ₂）的耐用，灵敏，选择性非酶电化学传感器的开发。新型的BA修饰的CN点包裹的Cu ₂ O-纳米蛙卵（FS @ CN-dot）传感器探针表现出对H ₂ O ₂的催化性能，可以在低还原电位下进行高灵敏度的电化学检测。使用表面分析方法分析了所制备的CN点包裹的Cu ₂ O异质结构纳米复合材料，以确认各种成分和掺杂元素的形态，结晶度和氧化态。此外，Cu ₂的形态分析O纳米颗粒表明Cu ₂ O保留了青蛙状的结构。在优化的实验条件下，传感器显示H ₂ O _2的动态范围很广，从0.5μM到9 mM，检测极限（LD）为1.2±0.1 nM。设计的传感探针即使在存在潜在干扰分子的情况下也显示出良好的稳定性，高灵敏度和选择性。为了检查所制造的传感器在生物医学应用中的可靠性，所提出的传感探头已成功应用于监测H ₂ O ₂在牙龈疾病患者的唾液中。就我们所知，该报告是同类研究中的第一篇，不仅因为其在CN来源方面具有新颖的构建风格，而且在实际样本适用性方面也是如此。

更新日期：2020-03-22

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