Design of a New Non‐enzymatic Sensor Based on a Substituted A2BO4+δ Perovskite for the Voltammetric Detection of Glucose,Electroanalysis

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Design of a New Non‐enzymatic Sensor Based on a Substituted A2BO4+δ Perovskite for the Voltammetric Detection of Glucose
Electroanalysis ( IF 2.7 ) Pub Date : 2020-04-17 , DOI: 10.1002/elan.202000062
Imane Boubezari _{1,

2} , Ali Zazoua ₁ , François Bessueille ₂ , Abdelhamid Errachid ₂ , Nicole Jaffrezic‐Renault ₂

Affiliation

Instant determination of glucose levels is necessary to monitor the treatment of diabetes. The next generation of electrochemical sensors aims to eliminate the use of enzymes because of their lack of stability and the complex procedure to immobilize them on the electrode. In this paper Pr_1.92Ba_0.08Ni0.₉₅Zn_0.05O_4+δ perovskite, a A₂BO_4+δ type, was tested, for the first time for non enzymatic detection of glucose. It was synthesized by a sol‐gel method. The obtained crystallized powder was structurally characterized by XRD, morphologically characterized by SEM and EDX and electrochemically characterized. A monoclinic crystallographic system was formed. The presence of Pr₂O₃ during synthesis and calcination is in agreement with the formation of defects in the crystalline network and the disproportionation of Ni^III sites into Ni^II and Ni^IV, due to the substitution of Pr by Ba. The oxido‐reduction of Ni^II sites is observed by cyclic voltammetry. The electrocatalytic oxidation of glucose through the electrooxidized Ni^II site was observed on a gold electrode, at 481 mV. The analytical performance of this glucose sensor is good in comparison to previously published ABO₃ perovskite modified electrodes, in terms of dynamic range (1.5 μM–7000 μM) and detection limit (0.5 μM). Its application to human serum shows that there is no interference for glucose detection.

中文翻译：

基于取代的A2BO4 +δ钙钛矿的新型非酶传感器用于葡萄糖伏安检测的设计

葡萄糖水平的即时测定对于监测糖尿病的治疗是必要的。下一代电化学传感器的目的是消除酶的使用，因为它们缺乏稳定性以及将酶固定在电极上的复杂过程。本文中Pr _1.92 Ba _0.08 Ni0。₉₅ Zn _0.05 O _{4 +δ}钙钛矿，A ₂ BO _{4 +δ}首次进行非酶检测葡萄糖测试。它是通过溶胶凝胶法合成的。所获得的结晶粉末通过XRD进行结构表征，通过SEM和EDX进行形态表征并且进行电化学表征。形成了单斜晶体学系统。合成和煅烧过程中Pr ₂ O ₃的存在与晶体网络中缺陷的形成以及由于Ba取代Pr导致Ni ^III位点歧化为Ni ^II和Ni ^IV相一致。通过循环伏安法观察到Ni ^II位的氧化还原。镍通过电氧化镍进行电催化氧化在金电极上以481 mV观察到^II位。与动态范围（1.5 μM–7000μM）和检测限（0.5μM）相比，该葡萄糖传感器的分析性能与先前发布的ABO ₃钙钛矿修饰电极相比性能良好。它在人血清中的应用表明对葡萄糖检测没有干扰。

更新日期：2020-04-17

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