Electrochemical Sensing of Flutamide Contained in Plasma and Urine Matrices Using NiFe2O4/rGO Nanocomposite, as an Efficient and Selective Electrocatalyst,Electroanalysis

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Electrochemical Sensing of Flutamide Contained in Plasma and Urine Matrices Using NiFe2O4/rGO Nanocomposite, as an Efficient and Selective Electrocatalyst
Electroanalysis ( IF 2.7 ) Pub Date : 2020-04-01 , DOI: 10.1002/elan.202000048
Ali Asghar Ensafi ₁ , Bahareh Mandian Talkhooncheh ₁ , Navid Zandi‐Atashbar ₁ , Behzad Rezaei ₁

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In this article, we report on the synthesis and new employment of magnetic nickelferrite oxide nanoparticles decorated reduced graphene oxide (NiFe₂O₄/rGO) to electrochemically sensing of flutamide. The preparation of this electrocatalyst was first assessed using various analytical instrumental techniques including FT‐IR spectroscopy, X‐ray diffraction spectroscopy, energy‐dispersive X‐ray spectroscopy, and field emission scanning and transmission electron microscopy. Besides, its electrochemical performance was investigated utilizing some electrochemical methods such as cyclic and differential pulse voltammetry, and also electrochemical impedance spectroscopy. The findings of this research are especially relevant for sensing flutamide in aqueous and biological samples. At the optimized conditions, the electrochemical sensor showed a linear range of 0.24–40.0 μmol L⁻¹, the detection limit of 0.05 μmol L⁻¹ flutamide, calibration sensitivity of 1.016 μA/μmol L⁻¹, and repeatability and reproducibility of 1.7 % and 4.1 %, respectively. The selectivity of the method was investigated in the presence of ions, and species can generally exist in the biological medium. The resulting data of the present work represented that this type of magnetic nanocomposites is suitable for selective detection of flutamide in real samples of plasma and urine. The recoveries obtained for flutamide analyses represented lower than 5.0 percent of relative error in these real samples.

中文翻译：

NiFe2O4 / rGO纳米复合材料作为高效选择性电催化剂对血浆和尿液中氟他胺的电化学感应

在本文中，我们报告了装饰性还原氧化石墨烯（NiFe ₂ O ₄/ rGO）以电化学方式检测氟他胺。首先使用各种分析仪器技术对这种电催化剂的制备进行评估，包括FT-IR光谱，X射线衍射光谱，能量分散X射线光谱以及场发射扫描和透射电子显微镜。此外，利用一些电化学方法，如循环和差分脉冲伏安法，以及电化学阻抗谱，研究了其电化学性能。这项研究的发现特别适用于感测水性和生物样品中的氟他胺。在最佳条件下，电化学传感器的线性范围为0.24–40.0μmolL ^-1，检测极限为0.05μmolL ^-1氟他米特，校准灵敏度为1.016μA/μmolL ^-1，重复性和重现性分别为1.7％和4.1％。在存在离子的情况下研究了该方法的选择性，并且物种通常可以存在于生物介质中。本工作的结果数据表明，这种类型的磁性纳米复合材料适用于在血浆和尿液的真实样品中选择性检测氟他胺。在这些实际样品中，氟他胺分析的回收率均低于相对误差的5.0％。

更新日期：2020-04-01

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