当前位置：
X-MOL 学术
›
J. Neuroendocrinol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2020-04-17 , DOI: 10.1111/jne.12856 Colin H Brown 1 , Mike Ludwig 2, 3 , Jeffrey G Tasker 4 , Javier E Stern 5
Journal of Neuroendocrinology ( IF 3.3 ) Pub Date : 2020-04-17 , DOI: 10.1111/jne.12856 Colin H Brown 1 , Mike Ludwig 2, 3 , Jeffrey G Tasker 4 , Javier E Stern 5
Affiliation
|
Somato‐dendritic secretion was first demonstrated over 30 years ago. However, although its existence has become widely accepted, the function of somato‐dendritic secretion is still not completely understood. Hypothalamic magnocellular neurosecretory cells were among the first neuronal phenotypes in which somato‐dendritic secretion was demonstrated and are among the neurones for which the functions of somato‐dendritic secretion are best characterised. These neurones secrete the neuropeptides, vasopressin and oxytocin, in an orthograde manner from their axons in the posterior pituitary gland into the blood circulation to regulate body fluid balance and reproductive physiology. Retrograde somato‐dendritic secretion of vasopressin and oxytocin modulates the activity of the neurones from which they are secreted, as well as the activity of neighbouring populations of neurones, to provide intra‐ and inter‐population signals that coordinate the endocrine and autonomic responses for the control of peripheral physiology. Somato‐dendritic vasopressin and oxytocin have also been proposed to act as hormone‐like signals in the brain. There is some evidence that somato‐dendritic secretion from magnocellular neurosecretory cells modulates the activity of neurones beyond their local environment where there are no vasopressin‐ or oxytocin‐containing axons but, to date, there is no conclusive evidence for, or against, hormone‐like signalling throughout the brain, although it is difficult to imagine that the levels of vasopressin found throughout the brain could be underpinned by release from relatively sparse axon terminal fields. The generation of data to resolve this issue remains a priority for the field.
中文翻译：
内分泌和自主神经调节中的体细胞树突加压素和催产素分泌。
30多年前首次证实了体细胞树突状分泌。然而，尽管体细胞树突分泌的存在已被广泛接受，但其功能仍不完全清楚。下丘脑大细胞神经分泌细胞是最早证实体树突分泌的神经元表型之一，也是体树突分泌功能最能表征的神经元之一。这些神经元以顺行方式从垂体后叶的轴突分泌神经肽、加压素和催产素进入血液循环，以调节体液平衡和生殖生理。加压素和催产素的逆行体细胞树突分泌调节分泌它们的神经元的活性以及邻近神经元群的活动，以提供协调内分泌和自主反应的群体内和群体间信号。外周生理的控制。躯体树突加压素和催产素也被认为可以在大脑中充当激素样信号。有一些证据表明，大细胞神经分泌细胞的体细胞树突分泌调节神经元的活动，超出其局部环境，在该环境中不存在含有加压素或催产素的轴突，但迄今为止，没有确凿的证据支持或反对激素-就像整个大脑的信号传导一样，尽管很难想象整个大脑中发现的加压素水平可以通过相对稀疏的轴突末端区域的释放来支撑。生成数据来解决这个问题仍然是该领域的首要任务。
更新日期：2020-04-17
中文翻译：
内分泌和自主神经调节中的体细胞树突加压素和催产素分泌。
30多年前首次证实了体细胞树突状分泌。然而，尽管体细胞树突分泌的存在已被广泛接受，但其功能仍不完全清楚。下丘脑大细胞神经分泌细胞是最早证实体树突分泌的神经元表型之一，也是体树突分泌功能最能表征的神经元之一。这些神经元以顺行方式从垂体后叶的轴突分泌神经肽、加压素和催产素进入血液循环，以调节体液平衡和生殖生理。加压素和催产素的逆行体细胞树突分泌调节分泌它们的神经元的活性以及邻近神经元群的活动，以提供协调内分泌和自主反应的群体内和群体间信号。外周生理的控制。躯体树突加压素和催产素也被认为可以在大脑中充当激素样信号。有一些证据表明，大细胞神经分泌细胞的体细胞树突分泌调节神经元的活动，超出其局部环境，在该环境中不存在含有加压素或催产素的轴突，但迄今为止，没有确凿的证据支持或反对激素-就像整个大脑的信号传导一样，尽管很难想象整个大脑中发现的加压素水平可以通过相对稀疏的轴突末端区域的释放来支撑。生成数据来解决这个问题仍然是该领域的首要任务。
京公网安备 11010802027423号