The effects of HIV on the gastrointestinal tract (GIT), including CD4 depletion, epithelial disruption, and collagen deposition, are well documented and only partially reversed by combination antiretroviral therapy (cART). However, the effects of HIV on the female reproductive tract (FRT) are poorly understood, and most studies have focused on ectocervix and vagina without assessing the upper tract. Here, we investigated CD4⁺ T‐cell frequency, phenotype, and HIV‐specific T‐cell responses in the endocervix and endometrium of HIV‐infected women, comparing these tissues to the GIT.

中文翻译：

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艾滋病毒感染妇女生殖和胃肠道黏膜黏膜免疫的平行研究。

HIV对胃肠道（GIT）的影响（包括CD4耗竭，上皮细胞破坏和胶原蛋白沉积）已得到充分证明，并且只有抗逆转录病毒联合疗法（cART）才能部分逆转。但是，对艾滋病毒对女性生殖道（FRT）的影响了解甚少，并且大多数研究都集中在子宫颈和阴道上，而没有评估上道。在这里，我们调查了HIV感染妇女的子宫颈和子宫内膜的CD4 ⁺ T细胞频率，表型和HIV特异性T细胞反应，并将这些组织与GIT进行了比较。