当前位置：
X-MOL 学术
›
J. Food Biochem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Esculetin and idebenone ameliorate galactose-induced cataract in a rat model.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-16 , DOI: 10.1111/jfbc.13230 Nermin Abdel Hamid Sadik 1 , Noha Ahmed El-Boghdady 1 , Nesreen Nabil Omar 2 , Hager Abd Al-Hamid 2
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-16 , DOI: 10.1111/jfbc.13230 Nermin Abdel Hamid Sadik 1 , Noha Ahmed El-Boghdady 1 , Nesreen Nabil Omar 2 , Hager Abd Al-Hamid 2
Affiliation
|
Cataract is the principal cause of blindness. The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose‐induced cataract. Rats were partitioned into four groups each of ten rats. Control group was fed with normal diet; group 2 rats were fed with galactose diet (50%); groups 3, 4 rats were fed with galactose diet concurrently with either esculetin (50 mg/kg BW) or idebenone (100 mg/kg BW), for 20 days. The study revealed that esculetin and idebenone significantly reduced the elevated levels of Bax/Bcl‐2 ratio, malondialdehyde, and DNA fragmentation and increased total antioxidant capacity level in lenses compared to the cataract‐induced group. Only esculetin decreased AR, galactitol, and advanced glycated end products levels in lenses. Histopathological examinations supported the biochemical findings. Esculetin and idebenone may have chemopreventive effects for sugar cataract.
中文翻译：
Esculetin和艾地苯醌改善大鼠模型中的半乳糖诱发的白内障。
白内障是失明的主要原因。醛糖还原酶（AR）是多元醇途径中的关键角色。多元醇的积累和氧化应激是白内障发生的主要原因。这项研究调查了七叶皂苷和艾地苯醌在半乳糖诱发的白内障中的细胞保护特性。将大鼠分成每十只大鼠四组。对照组饮食正常。第2组大鼠半乳糖饮食（50％）；第3组，对4只大鼠用半乳糖饮食同时加七叶皂甙（50 mg / kg BW）或艾地苯醌（100 mg / kg BW）喂养20天。该研究表明，与白内障诱发组相比，七叶皂甙和艾地苯醌显着降低了镜片中Bax / Bcl-2比，丙二醛和DNA碎片的升高水平，并增加了镜片的总抗氧化能力。只有七叶皂甙降低了镜片中的AR，半乳糖醇和先进的糖化终产物水平。组织病理学检查支持生化结果。Esculetin和艾地苯醌可能对糖性白内障具有化学预防作用。
更新日期：2020-04-16
中文翻译：
Esculetin和艾地苯醌改善大鼠模型中的半乳糖诱发的白内障。
白内障是失明的主要原因。醛糖还原酶（AR）是多元醇途径中的关键角色。多元醇的积累和氧化应激是白内障发生的主要原因。这项研究调查了七叶皂苷和艾地苯醌在半乳糖诱发的白内障中的细胞保护特性。将大鼠分成每十只大鼠四组。对照组饮食正常。第2组大鼠半乳糖饮食（50％）；第3组，对4只大鼠用半乳糖饮食同时加七叶皂甙（50 mg / kg BW）或艾地苯醌（100 mg / kg BW）喂养20天。该研究表明，与白内障诱发组相比，七叶皂甙和艾地苯醌显着降低了镜片中Bax / Bcl-2比，丙二醛和DNA碎片的升高水平，并增加了镜片的总抗氧化能力。只有七叶皂甙降低了镜片中的AR，半乳糖醇和先进的糖化终产物水平。组织病理学检查支持生化结果。Esculetin和艾地苯醌可能对糖性白内障具有化学预防作用。
京公网安备 11010802027423号