The effects of intermittent hypoxic training or conditioning on many pathological conditions have been widely investigated. One of the pathological conditions dealt with intermittent hypoxic training is ischemic stroke. Well-known mechanisms of intermittent hypoxia-induced protection are related to increased energy metabolism and the enhanced antioxidant effects. In the last decades, the role of microglia in the progress of ischemic stroke-related brain damage has been focused. The dual-edge function of microglia indicates that the microglia-mediated inflammatory response is definitely beneficial in the early stage of ischemic stroke, but long-term activation of microglia is rather detrimental during the recovery process. The effect of IHT on microglia polarization is not investigated. This study focused on whether IHT regulates the polarization of microglia without dampening its classic phagocytic function. This study will provide pivotal information regarding the effects of IHT on the long-term effects on the recovery process from ischemic stroke.

中文翻译：

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常压间歇性低氧训练可调节小胶质细胞表型并增强吞噬细胞活性。

间歇性低氧训练或调节对许多病理状况的影响已被广泛研究。间歇性缺氧训练引起的病理状况之一是缺血性中风。间歇性缺氧引起的保护的众所周知的机制与能量代谢的增加和抗氧化作用的增强有关。在过去的几十年里，小胶质细胞在缺血性中风相关脑损伤进展中的作用一直受到关注。小胶质细胞的双重功能表明，小胶质细胞介导的炎症反应在缺血性中风的早期阶段肯定是有益的，但小胶质细胞的长期激活在恢复过程中却是相当有害的。尚未研究 IHT 对小胶质细胞极化的影响。这项研究的重点是 IHT 是否调节小胶质细胞的极化而不削弱其经典的吞噬功能。这项研究将提供关于 IHT 对缺血性中风恢复过程的长期影响的关键信息。