Saliva: potential diagnostic value and transmission of 2019-nCoV.,International Journal of Oral Science

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Saliva: potential diagnostic value and transmission of 2019-nCoV.
International Journal of Oral Science ( IF 10.8 ) Pub Date : 2020-04-17 , DOI: 10.1038/s41368-020-0080-z
Ruoshi Xu ₁ , Bomiao Cui ₂ , Xiaobo Duan ₁ , Ping Zhang ₂ , Xuedong Zhou ₂ , Quan Yuan ₁

Affiliation

2019-nCoV epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now. Saliva, a biofluid largely generated from salivary glands in oral cavity, has been reported 2019-nCoV nucleic acid positive. Besides lungs, salivary glands and tongue are possibly another hosts of 2019-nCoV due to expression of ACE2. Close contact or short-range transmission of infectious saliva droplets is a primary mode for 2019-nCoV to disseminate as claimed by WHO, while long-distance saliva aerosol transmission is highly environment dependent within indoor space with aerosol-generating procedures such as dental practice. So far, no direct evidence has been found that 2019-nCoV is vital in air flow for long time. Therefore, to prevent formation of infectious saliva droplets, to thoroughly disinfect indoor air and to block acquisition of saliva droplets could slow down 2019-nCoV dissemination. This review summarizes diagnostic value of saliva for 2019-nCoV, possibly direct invasion into oral tissues, and close contact transmission of 2019-nCoV by saliva droplets, expecting to contribute to 2019-nCoV epidemic control.

中文翻译：

唾液：2019-nCoV 的潜在诊断价值和传播。

2019-nCoV 疫情于 2019 年 12 月下旬首次报道，目前已导致 COVID-19 在全球爆发。唾液是一种主要由口腔唾液腺产生的生物液体，据报道 2019-nCoV 核酸呈阳性。除肺外，由于 ACE2 的表达，唾液腺和舌头可能是 2019-nCoV 的另一个宿主。世卫组织声称，传染性唾液飞沫的近距离接触或短程传播是 2019-nCoV 传播的主要方式，而远距离唾液气溶胶传播高度依赖于室内空间内的环境，其中包括牙科诊所等气溶胶产生过程。迄今为止，尚未发现直接证据表明2019-nCoV长期对空气流动至关重要。因此，为了防止形成传染性唾液飞沫，彻底消毒室内空气并阻止唾液飞沫的获取可以减缓 2019-nCoV 的传播。该综述总结了唾液对2019-nCoV的诊断价值、可能直接侵入口腔组织以及通过唾液飞沫传播2019-nCoV的密切接触传播，期望为2019-nCoV疫情控制做出贡献。

更新日期：2020-04-24

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