Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal importance. In recent years, the discovery of new anti-inflammatory agents as selective COX-2 inhibitors has acquired more attention. This is due to the fact that currently available COX-2 inhibitors are linked with adverse effects. Various new organic scaffolds are being explored as new COX-2 inhibitors. In this review, we have mainly described different chemical scaffolds which have been investigated for COX-2 inhibition and anti-inflammatory activity. In the current review, literature from the last 10 years has been included. It will be helpful for organic and medicinal chemists to scrutinize new agents with minimum side effects.

中文翻译：

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选择性环氧合酶2抑制剂：具有抗炎和COX-2抑制活性的近期化学支架的综述

选择性环氧合酶2（COX-2）抑制剂具有显着的医学重要性。近年来，作为选择性COX-2抑制剂的新型抗炎剂的发现已引起更多关注。这是由于当前可用的COX-2抑制剂与不良反应有关的事实。人们正在探索各种新型有机支架作为新型COX-2抑制剂。在这篇综述中，我们主要描述了针对COX-2抑制和抗炎活性进行研究的不同化学支架。在当前的审查中，包括了过去十年的文献。对有机和药物化学家仔细研究具有最小副作用的新药物将很有帮助。