Molecular hybridization has become a new promising way to treat multifactorial diseases with a single compound that acts on multiple targets. The combination of several functional pharmacophore groups in one molecule can lead to a stronger therapeutic effect due to the ability to bind to several targets and possible synergistic interactions. The concept of multifunctional agents is being actively developed and has already produced some encouraging results. The quinazoline cycle and hydroxamic acids are unique pharmacophore groups that contribute to the structure of drug agents widely used in medical chemistry. The combination of these pharmacophores in one molecule leads to promising new compounds, which has been confirmed by many experimental studies in published literature across the world. Hybrid compounds of hydroxamic acids and the quinazoline cycle are a potential basis for the development of effective drugs used in the complex treatment of oncological, infectious and neurological diseases. This review provides information on the most significant developments in this area and discusses the bioactivity of important agents. Compounds with both linear hydroxamic acids and cyclic acids in which a hydroxamate group is integrated in the quinazoline ring are also covered in this review.

中文翻译：

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具有生物活性的喹唑啉基异羟肟酸

分子杂交已成为一种作用于多种靶标的单一化合物来治疗多因素疾病的新方法。一个分子中几个功能性药效基团的结合，由于具有与多个靶标结合的能力以及可能的协同相互作用，可导致更强的治疗效果。多功能代理的概念正在积极发展中，并且已经产生了令人鼓舞的结果。喹唑啉循环和异羟肟酸是独特的药效基团，它们有助于在医学化学中广泛使用的药物结构。这些药效团在一个分子中的组合产生了有希望的新化合物，这已被世界各地已发表文献中的许多实验研究所证实。异羟肟酸和喹唑啉循环的杂合化合物是开发用于肿瘤，传染病和神经疾病综合治疗的有效药物的潜在基础。这篇综述提供了有关该领域最重要进展的信息，并讨论了重要药物的生物活性。这篇综述还涵盖了具有线性异羟肟酸和环酸的化合物，其中异羟肟酸酯基团整合在喹唑啉环中。