Beyond structure: emerging approaches to study GPCR dynamics.,Current Opinion in Structural Biology

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Beyond structure: emerging approaches to study GPCR dynamics.
Current Opinion in Structural Biology ( IF 6.1 ) Pub Date : 2020-04-16 , DOI: 10.1016/j.sbi.2020.03.004
Anastasiia Gusach ₁ , Ivan Maslov ₁ , Aleksandra Luginina ₁ , Valentin Borshchevskiy ₂ , Alexey Mishin ₁ , Vadim Cherezov ₃

Affiliation

G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins that are involved in regulation of sensory and physiological processes and implicated in many diseases. The last decade revolutionized the GPCR field by unraveling multiple high-resolution structures of many different receptors in complexes with various ligands and signaling partners. A complete understanding of the complex nature of GPCR function is, however, impossible to attain without combining static structural snapshots with information about GPCR dynamics obtained by complementary spectroscopic techniques. As illustrated in this review, structure and dynamics studies are now paving the way for understanding important questions of GPCR biology such as partial and biased agonism, allostery, oligomerization, and other fundamental aspects of GPCR signaling.

中文翻译：

超越结构：研究GPCR动力学的新兴方法。

G蛋白偶联受体（GPCR）构成了最大的膜蛋白超家族，涉及调节感觉和生理过程，并涉及许多疾病。在过去的十年中，通过揭示具有各种配体和信号配体的复合物中许多不同受体的多个高分辨率结构，彻底改变了GPCR领域。但是，如果不将静态结构快照与通过补充光谱技术获得的有关GPCR动力学的信息结合起来，就不可能完全了解GPCR功能的复杂性。如本评论所述，结构和动力学研究为理解GPCR生物学的重要问题铺平了道路，例如部分和偏向激动，变构，寡聚，

更新日期：2020-04-16

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