C-type lectins (CTLs) are key recognition proteins in shrimp immunity. A few years ago we reviewed sequence information, ligand specificity, expression profiles and specific functions of the shrimp CTLs. Since then, multiple integrated studies that implemented biochemical approaches using both the native and recombinant proteins, functional genetic approaches using RNA interference, and mechanistic studies by analyzing protein-protein interactions were carried out. Results from these rigorous studies revealed the functions and mechanisms of action of selected members of the shrimp CTL family. This review focuses on this new knowledge, that includes unique structural aspects, functions, and mechanisms in host-pathogen interactions, the functional relevance of regions other than the C-type lectin domain, and the regulation of transcription of shrimp CTLs. Thus, this review aims to provide a detailed update of recent studies that have contributed to our better understanding of the shrimp immune events that involve CTL functions.

中文翻译：

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虾 C 型凝集素在宿主-病原体相互作用中的功能相关性。

C 型凝集素 (CTL) 是虾免疫中的关键识别蛋白。几年前，我们回顾了虾 CTL 的序列信息、配体特异性、表达谱和特定功能。从那时起，进行了多项综合研究，包括使用天然和重组蛋白的生化方法、使用 RNA 干扰的功能遗传方法以及通过分析蛋白质-蛋白质相互作用的机制研究。这些严格研究的结果揭示了虾 CTL 家族选定成员的功能和作用机制。本综述重点关注这一新知识，包括宿主-病原体相互作用中独特的结构方面、功能和机制，C 型凝集素域以外区域的功能相关性，以及对虾 CTL 转录的调控。因此，本综述旨在提供最近研究的详细更新，这些研究有助于我们更好地了解涉及 CTL 功能的虾免疫事件。