Honey is a natural product, containing flavonoids and phenolic acids, appreciated for its therapeutic abilities since ancient times. Although the bioactive potential is linked to the composition, that is variable depending on mainly the botanical origin, honey has antioxidant and anti-inflammatory properties. Therefore, honey, administered alone or in combination with conventional therapy, might result useful in the management of chronic diseases that are commonly associated with oxidative stress and inflammation state. Obesity is a metabolic disorder characterized by visceral adiposity. The adipose tissue becomes hypertrophic and undergoes hyperplasia, resulting in a hypoxic environment, oxidative stress and production of pro-inflammatory mediators that can be responsible for other disorders, such as metabolic syndrome and neurodegeneration. Experimental evidence from animals have shown that honey improves glycemic control and lipid profile with consequent protection from endothelial dysfunction and neurodegeneration. The purpose of the present review is to summarize the current literature concerning the beneficial effects of honey in the management of the obesity-related dysfunctions, including neurodegeneration. Based on the key constituents of honey, the paper also highlights polyphenols to be potentially responsible for the health benefits of honey. Further well-designed and controlled studies are necessary to validate these benefits in humans.

蜂蜜是一种天然产品，其中含有类黄酮和酚酸，自古以来就具有治疗能力。尽管生物活性潜力与组成有关，但主要取决于植物来源而有所不同，但蜂蜜具有抗氧化剂和抗炎特性。因此，单独或与常规疗法联合施用的蜂蜜可能会有助于管理通常与氧化应激和炎症状态相关的慢性疾病。肥胖是一种以内脏脂肪为特征的代谢疾病。脂肪组织变得肥大并经历增生，从而导致缺氧环境，氧化应激和促炎介质的产生，这些介质可能导致其他疾病，例如代谢综合征和神经退行性变。来自动物的实验证据表明，蜂蜜改善了血糖控制和脂质分布，从而保护了内皮功能和神经变性。本综述的目的是总结有关蜂蜜在治疗与肥胖相关的功能障碍（包括神经变性）中的有益作用的现有文献。基于蜂蜜的关键成分，该论文还强调了多酚可能对蜂蜜的健康有益。为了验证这些对人体的益处，需要进行进一步设计和控制良好的研究。本综述的目的是总结有关蜂蜜在治疗与肥胖相关的功能障碍（包括神经退行性疾病）中的有益作用的现有文献。基于蜂蜜的关键成分，该论文还强调了多酚可能对蜂蜜的健康有益。为了验证这些对人体的益处，需要进行进一步设计和控制良好的研究。本综述的目的是总结有关蜂蜜在治疗与肥胖相关的功能障碍（包括神经变性）中的有益作用的现有文献。基于蜂蜜的关键成分，该论文还强调了多酚可能对蜂蜜的健康有益。为了验证这些对人体的益处，需要进行进一步设计和控制良好的研究。