This study aims to examine the effects of cystine and theanine (CT), which increases glutathione biosynthesis, on the survival rate and acute radiation injury of the small intestine and bone marrow using a rat model. CT pre-treatment (280 mg/kg for 5 days) significantly improved weight loss and survival rate of rats as compared with the control group after 5 Gy. CT pre-treatment significantly increased the rate of mucosa and crypt length, and decreased the number of apoptotic cells, TUNEL and cleaved caspase-3 positive cells, while increasing the number of mitotic cells and Ki-67 positive cells in jejunal crypts and villi compared to control rats post-irradiation. CT also suppressed bone marrow cell loss and reduced the number of apoptotic cells in bone marrow. These results suggest a protective effect of CT pre-treatment for acute injury after irradiation through apoptosis inhibition and increased proliferative activity in jejunal crypt cells and bone marrow cells.

这项研究旨在使用大鼠模型研究胱氨酸和茶氨酸（CT）增强谷胱甘肽生物合成的作用，对小肠和骨髓的存活率以及急性放射损伤的影响。CT预处理（280 mg / kg，5天）与5 Gy后的对照组相比，显着改善了大鼠的体重减轻和存活率。CT预处理显着提高了空肠隐窝和绒毛中粘膜的比率和隐窝长度，并减少了凋亡细胞，TUNEL和裂解的caspase-3阳性细胞的数量，同时增加了空肠隐窝和绒毛中的有丝分裂细胞和Ki-67阳性细胞的数量。控制辐照后的大鼠。CT还可以抑制骨髓细胞的流失并减少骨髓中凋亡细胞的数量。