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Functional characterization of the antiepileptic drug candidate, padsevonil, on GABA A receptors
Epilepsia ( IF 6.6 ) Pub Date : 2020-04-16 , DOI: 10.1111/epi.16497
Isabelle Niespodziany 1 , Philippe Ghisdal 1 , Brice Mullier 1 , Martyn Wood 1 , Laurent Provins 1 , Rafal M Kaminski 1 , Christian Wolff 1
Affiliation  

The antiepileptic drug candidate, padsevonil, is the first in a novel class of drugs designed to interact with both presynaptic and postsynaptic therapeutic targets: synaptic vesicle 2 proteins and γ‐aminobutyric acid type A receptors (GABAARs), respectively. Functional aspects of padsevonil at the postsynaptic target, GABAARs, were characterized in experiments reported here.

中文翻译:

抗癫痫药物候选物 padsevonil 对 GABA A 受体的功能表征

抗癫痫药物候选药物 padsevonil 是设计用于与突触前和突触后治疗靶点相互作用的一类新型药物中的第一种:突触囊泡 2 蛋白和γ-氨基丁酸 A 型受体 (GABAARs),分别。在这里报道的实验中表征了 padsevonil 在突触后靶标 GABAARs 的功能方面。
更新日期:2020-04-16
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