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Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats: Potential neurophysiological basis for intermittent as an alternative to continuous stimulation
Epilepsia ( IF 5.6 ) Pub Date : 2020-04-16 , DOI: 10.1111/epi.16498
Mathieu Sprengers 1 , Robrecht Raedt 1 , Lars Emil Larsen 1 , Jean Delbeke 1 , Wytse Jan Wadman 2 , Paul Boon 1 , Kristl Vonck 1
Affiliation  

Deep brain stimulation (DBS) is an increasingly applied treatment for various neuropsychiatric disorders including drug‐resistant epilepsy, and it may be optimized by rationalizing the stimulation protocol based on increased knowledge of its mechanism of action. We evaluated the effects of minutes to hours of hippocampal DBS on hippocampal evoked potentials (EPs) and local field potentials (LFPs) in freely moving male rats to further investigate some of the previously proposed mechanisms of action.

中文翻译:

深部脑刺激通过双时间过程降低自由运动大鼠的诱发电位:间歇性替代连续刺激的潜在神经生理学基础

脑深部刺激 (DBS) 越来越多地应用于治疗各种神经精神疾病,包括耐药性癫痫,并且可以通过基于对其作用机制的更多了解来合理化刺激方案来优化它。我们评估了几分钟到几小时的海马 DBS 对自由移动雄性大鼠海马诱发电位 (EP) 和局部场电位 (LFP) 的影响,以进一步研究一些先前提出的作用机制。
更新日期:2020-04-16
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