Manic-depressive illness has too often been outshined by Bipolar Disorders (BD). Young psychiatrists risk forgetting the tight link between mania and depression and regard the two poles of illness as separate entities. This approach is unsupported by historical and psychopathological standpoints. Malhi's and colleagues recently proposed ACE (Activity, Cognition and Emotion) model, which is based on Weygandt's and Kraepelin's observations (1), encourages the framing of BD in a larger perspective.

中文翻译：

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ACE模型的神经生物学观点。

躁狂抑郁症常常被躁郁症（BD）击败。年轻的精神科医生可能会忘记躁狂症和抑郁症之间的紧密联系，并将疾病的两个极端视为独立的实体。历史和心理病理学观点均不支持这种方法。Malhi和同事最近提出了ACE（活动，认知和情感）模型，该模型基于Weygandt和Kraepelin的观察结果（1），鼓励从更大的角度构建BD。