ABSTRACT

Polychlorinated biphenyls (PCBs) were used in technical mixtures of different PCB congeners as hydraulic fluids in underground mining in Germany in North Rhine-Westphalia, Ibbenbueren, and Saarland from the mid-1960s to 1986. Mine workers who were involved in maintenance and repair or operation of hydraulically driven machines in underground mines were potentially exposed to liquids containing PCBs. The aim of the present study was to investigate whether this potential exposure which occurred more than 30 years ago was still detectable. Biomonitoring and a structured work anamnesis were conducted on a representative sample of 210 miners. PCBs in plasma were measured by gas chromatography coupled to mass spectrometry with an LOQ of 0.01 µg/L plasma for all congeners. The primary aim was comparison of the number of exceedances of the underlying comparative values for PCB congeners with those of the general population. Secondary endpoint was the question whether there were regional differences in potential PCB exposure. The biomonitoring showed a significant difference for PCB 74 with N= 94 (45%); for PCB 114 with N = 64 (31%) and for PCB 99 and PCB 105 with N = 23 (11%) and N = 19 (9%) of 210 measurements above the reference value compared to the general population (5%). The all over detection frequencies (µg/L plasma median | SD | min |max) of these congeners were as follows:

PCB 74: 0.128 | 0.481 | < LOD | 3.098; PCB 99:0.035 | 0.078 | < LOD | 0.582

PCB 105: 0.005 | 0.031 | < LOD | 0.307; PCB 114:0.005 | 0.024 | < LOD | 0.140

Regional differences were not detectable.

摘要

从 1960 年代中期到 1986 年，在德国北莱茵-威斯特法伦州、伊本布伦和萨尔州的地下采矿中，多氯联苯 (PCB) 被用于不同 PCB 同系物的技术混合物中作为液压油。地下矿井中液压驱动机器的运行可能会暴露在含有多氯联苯的液体中。本研究的目的是调查这种 30 多年前发生的潜在暴露是否仍然可以检测到。对 210 名矿工的代表性样本进行了生物监测和结构化的工作记录。血浆中的多氯联苯通过气相色谱与质谱联用进行测量，所有同系物的 LOQ 为 0.01 µg/L 血浆。主要目的是比较多氯联苯同源物的基本比较值与普通人群的超出数量。次要终点是潜在 PCB 暴露是否存在地区差异的问题。生物监测显示 PCB 74 有显着差异，N= 94 (45%)；PCB 114 的 N = 64 (31%) 和 PCB 99 和 PCB 105 的 N = 23 (11%) 和 N = 19 (9%) 与一般人群 (5%) 相比，210 次测量值高于参考值. 这些同源物的全部检测频率（µg/L 血浆中值 | SD | min |max）如下：生物监测显示 PCB 74 有显着差异，N= 94 (45%)；PCB 114 的 N = 64 (31%) 和 PCB 99 和 PCB 105 的 N = 23 (11%) 和 N = 19 (9%) 与一般人群 (5%) 相比，210 次测量值高于参考值. 这些同源物的全部检测频率（µg/L 血浆中值 | SD | min |max）如下：生物监测显示 PCB 74 有显着差异，N= 94 (45%)；PCB 114 的 N = 64 (31%) 和 PCB 99 和 PCB 105 的 N = 23 (11%) 和 N = 19 (9%) 与一般人群 (5%) 相比，210 次测量值高于参考值. 这些同源物的全部检测频率（µg/L 血浆中值 | SD | min |max）如下：

PCB 74：0.128 | 0.481 | < 细节层次 | 3.098; 印刷电路板 99:0.035 | 0.078 | < 细节层次 | 0.582

PCB 105：0.005 | 0.031 | < 细节层次 | 0.307; 印刷电路板 114:0.005 | 0.024 | < 细节层次 | 0.140

区域差异未检测到。