Oil spill response and clean-up (OSRC) workers were exposed to hazardous airborne chemicals following the 2010 Deepwater Horizon disaster. The aim of this study was to evaluate lung function in workers 4–6 years following the disaster using a prospective cohort. Participants who completed two spirometry test sessions 1–3 years, and 4–6 years after the spill (N = 1,838) were included and forced expiratory volume in 1 s (FEV₁; ml), forced vital capacity (FVC; ml), and ratio (FEV₁/FVC; %) determined. Linear mixed models were utilized to estimate relationships between OSRC exposures and lung function 4–6 years after the spill and changes since the prior measurement. Despite suggestive reduced lung function at 1–3 years, at the 4–6-year exam workers with total hydrocarbon (THC) exposure 1–2.99 ppm and ≥3 ppm compared to those with ≤0.29 ppm exhibited higher FEV₁ (β: 108 ml, 95% CI: 17, 198) and (β: 118 ml, 95% CI: 5, 232), respectively. Compared with support workers, those in higher exposed jobs displayed greater improvement in FEV₁ between visits: cleanup on water (β: 143 ml, 95% CI: 35, 250), operations (β: 132 ml, 95% CI: 30, 234) and response (β: 149 ml, 95% CI: 43, 256). Greater FEV₁ improvement was also associated with higher versus the lowest level THC exposure: 1–2.99 ppm (β: 134 ml, 95% CI: 57, 210) and ≥3 ppm (β: 205 ml, 95% CI: 109, 301). Lung function decrements seen shortly after the spill were no longer apparent 4–6 years later, with the greatest improvement among those with the highest exposures.

在2010年“深水地平线”灾难之后，溢油应急响应和清理（OSRC）工人暴露于危险的航空化学品中。这项研究的目的是使用前瞻性队列研究评估灾后4-6年工人的肺功能。参加者在泄漏发生后的1-3年和泄漏后4-6年（N = 1,838）完成了两次肺活量测试，并在1 s（FEV ₁ ; ml），强制肺活量（FVC; ml），和比率（FEV ₁/ FVC; ％） 决心。线性混合模型用于估计溢漏后4-6年的OSRC暴露与肺功能之间的关系以及自先前测量以来的变化。尽管在1-3年时提示肺功能下降，但在4-6岁检查中，总碳氢化合物（THC）暴露为1-2.99 ppm和≥3ppm的工人比那些≤0.29ppm的工人表现出更高的FEV ₁（β：108毫升，95％CI：17，198）和（β：118毫升，95％CI：5，232）。与支持人员相比，暴露程度较高的人员在两次访问之间显示出FEV _1的更大改善：水净化（β：143 ml，95％CI：35，250），手术（β：132 ml，95％CI：30， 234）和反应（β：149 ml，95％CI：43，256）。更高的FEV ₁相对于最低水平的四氢大麻酚暴露水平的提高也可带来改善：1-2.99 ppm（β：134 ml，95％CI：57、210）和≥3ppm（β：205 ml，95％CI：109，301）。泄漏后不久，肺功能下降在4-6年后不再明显，在暴露量最高的肺中，改善最大。