Alemtuzumab infusion is rarely associated with serious cardiac toxicity. We report a case of acute troponin-negative chest pain with dynamic T-wave changes, immediately following first infusion of alemtuzumab in a patient with multiple sclerosis. The chest pain and ECG (electrocardiogram) changes improved with cessation of alemtuzumab and conservative management. The presumed cause was infusion-associated cytokine release, but the precise mechanism is unknown.

中文翻译：

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与阿仑单抗输注治疗多发性硬化症相关的急性心脏毒性

阿仑单抗输注很少与严重的心脏毒性相关。我们报告了一例伴有动态 T 波变化的急性肌钙蛋白阴性胸痛，在多发性硬化症患者首次输注阿仑单抗后立即发生。停止阿仑单抗和保守治疗后，胸痛和 ECG（心电图）变化得到改善。推测的原因是与输液相关的细胞因子释放，但确切的机制尚不清楚。