Multiple sclerosis (MS) is an immune-mediated, neurodegenerative disorder, characterized by central nervous system (CNS) inflammation.1 The cause of MS is unknown, and there is no cure. Despite the widespread availability of disease-modifying therapies (DMTs), MS continues to be an important cause of non-traumatic neurologic disability among young adults.1 Hence, there is a clinical impetus to identify modifiable factors that may ameliorate the risk of MS diagnosis and disease severity.

中文翻译：

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MS 中的加权证据：肥胖和神经变性

多发性硬化症 (MS) 是一种免疫介导的神经退行性疾病，其特征是中枢神经系统 (CNS) 炎症。1 MS 的病因尚不清楚，也无法治愈。尽管疾病改善疗法 (DMT) 已广泛应用，但 MS 仍然是年轻人非创伤性神经功能障碍的一个重要原因。 1 因此，临床上有动力去确定可以改善 MS 诊断风险的可改变因素和疾病的严重程度。