Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.

中文翻译：

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上皮间质转化研究的指南和定义。

上皮-间质转化 (EMT) 包括从上皮到间充质表型的细胞组织的动态变化，这导致细胞迁移和侵袭的功能变化。EMT 发生在多种生理和病理条件下，由一组保守的诱导信号、转录调节因子和下游效应子驱动。仅在 2019 年，Web of Science 就收录了 5,700 多篇出版物，EMT 的研究正在迅速扩大。这种日益增长的兴趣保证了研究人员在提及和开展 EMT 研究时需要达成共识。本共识声明由“EMT 国际协会”（TEMTIA）调解，是 EMT 研究人员历时 2 年讨论的结果，旨在澄清命名法并在未来出版物中为 EMT 研究提供定义和指南。我们相信这些指南将有助于减少对各种实验模型中产生的研究数据的误解和误解，并促进跨学科合作以识别和解决该研究领域的关键开放性问题。在认识到保持实验方法和概念框架多样性的重要性的同时，我们强调 EMT 研究对增加我们对发育过程和对抗癌症和其他疾病的理解的持久贡献取决于采用统一的术语来描述 EMT。我们相信这些指南将有助于减少对各种实验模型中产生的研究数据的误解和误解，并促进跨学科合作以识别和解决该研究领域的关键开放性问题。在认识到保持实验方法和概念框架多样性的重要性的同时，我们强调 EMT 研究对增加我们对发育过程和对抗癌症和其他疾病的理解的持久贡献取决于采用统一的术语来描述 EMT。我们相信这些指南将有助于减少对各种实验模型中产生的研究数据的误解和误解，并促进跨学科合作以识别和解决该研究领域的关键开放性问题。在认识到保持实验方法和概念框架多样性的重要性的同时，我们强调 EMT 研究对增加我们对发育过程和对抗癌症和其他疾病的理解的持久贡献取决于采用统一的术语来描述 EMT。