Abstract

One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1,3 hydride transfer in the presence of acid catalyst has been described. Substrate scope and mechanistic insights were investigated. Substituents on the amide side have a negligible influence on the key step and therefore the method have wide scope for accessing various bicyclic core structure.

Graphic abstract

A Mechanistic Insight into the Acid Catalyzed, One-Pot Synthesis of Isoindole-Fused Quinazolin 4-ones

中文翻译：

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机械观察到的酸催化一锅合成异吲哚稠合的喹唑啉四酮

摘要

已经描述了在酸催化剂存在下通过分子内的1，3氢化物转移一锅合成异吲哚稠合的喹唑啉4-酮。研究了基材的范围和机理的见解。酰胺侧的取代基对关键步骤的影响可忽略不计，因此该方法具有广泛的访问各种双环核心结构的范围。

图形摘要

机械观察到的酸催化一锅合成的异吲哚融合的喹唑啉4-ones。