当前位置: X-MOL 学术Arch. Environ. Contam. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Association Between Leukocyte Telomere Length and Serum Concentrations of PCBs and Organochlorine Pesticides.
Archives of Environmental Contamination and Toxicology ( IF 3.7 ) Pub Date : 2020-04-16 , DOI: 10.1007/s00244-020-00732-z
Behrooz Karimi 1 , Ramin Nabizadeh 2 , Masud Yunesian 2, 3
Affiliation  

Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) through food, water, and air occurred during the life, which may change telomere length (TL) in peripheral blood leukocytes. The present study was designed to investigate the association between TL and serum levels of PCBs and OCPs in Tehran male's population. Whole blood samples were randomly taken from 300 adult males, aged between 25 and 40 years. TL was determined by real-time PCR to measure the number of the telomere (T) repeats to the number of a single-copy gene (S). We applied the multivariate linear regression model to compare the effect of each lipid adjusted serum levels of PCBs and OCPs congener on the TL, with adjustment for age, body mass index, education, smoking, and food patterns. Each doubling of the nondioxin-like PCBs, dioxin-like PCBs, and OCPs levels were associated with 1.9% [95% confidence interval (CI) - 0.70 to 5.40%], 2.5% (95% CI 0.30-8.3%), and - 2.4% (95% CI - 0.70 to - 6.2%) variation in the TL, respectively. The percent difference in the TL with exposure to nondioxin-like PCBs, dioxin-like PCBs, and OCPs for participants with older than age 37 years were 6.45% (95% CI  2.81-16.50%), 4.52% (95% CI  1.60-10.54%), and - 7.44% (95% CI - 1.55 to - 15.51%), respectively. Exposures to nondioxin-like PCBs (except for PCB 28 and 52) with high chlorine in structure and dioxin-like PCBs were related to longer TLs. Conversely, serum levels of OCPs can be associated with oxidative stress and systemic inflammation that lead to telomere shortening.

中文翻译:

白细胞端粒长度与多氯联苯和有机氯农药的血清浓度之间的关联。

生命中通过食物,水和空气接触多氯联苯(PCB)和有机氯农药(OCP),这可能会改变外周血白细胞的端粒长度(TL)。本研究旨在调查德黑兰男性人口中TL与血清PCBs和OCPs水平之间的关联。从300名年龄在25至40岁之间的成年男性中随机抽取全血样本。通过实时PCR确定TL,以测量端粒(T)重复的数目至单拷贝基因(S)的数目。我们应用多元线性回归模型比较了每种脂质调整的血清PCBs和OCPs同系物对TL的影响,并调整了年龄,体重指数,教育程度,吸烟和饮食习惯。非二恶英类PCB,二恶英类PCB每增加一倍,和OCP含量分别为1.9%[95%置信区间(CI)-0.70至5.40%],2.5%(95%CI 0.30-8.3%)和-2.4%(95%CI-0.70至-6.2%) TL的变化。37岁以上参与者接触非二恶英样PCB,二恶英样PCB和OCP的TL中的百分比差异分别为6.45%(95%CI 2.81-16.50%),4.52%(95%CI 1.60- 10.54%)和-7.44%(95%CI-1.55至-15.51%)。结构中氯含量高的非二恶英类PCB(PCB 28和52除外)和类二恶英PCB的暴露与更长的TL有关。相反,OCP的血清水平可能与导致端粒缩短的氧化应激和全身性炎症有关。TL的差异分别为70%至-6.2%)。37岁以上参与者接触非二恶英样PCB,二恶英样PCB和OCP的TL中的百分比差异分别为6.45%(95%CI 2.81-16.50%),4.52%(95%CI 1.60- 10.54%)和-7.44%(95%CI-1.55至-15.51%)。结构中氯含量高的非二恶英类PCB(PCB 28和52除外)和类二恶英PCB的暴露与更长的TL有关。相反,OCP的血清水平可能与导致端粒缩短的氧化应激和全身性炎症有关。TL的差异分别为70%至-6.2%)。37岁以上参与者接触非二恶英样PCB,二恶英样PCB和OCP的TL中的百分比差异分别为6.45%(95%CI 2.81-16.50%),4.52%(95%CI 1.60- 10.54%)和-7.44%(95%CI-1.55至-15.51%)。结构中氯含量高的非二恶英类PCB(PCB 28和52除外)和类二恶英PCB的暴露与更长的TL有关。相反,OCPs的血清水平可能与导致端粒缩短的氧化应激和全身性炎症有关。55至-15.51%)。结构中氯含量高的非二恶英类PCB(PCB 28和52除外)和类二恶英PCB的暴露与更长的TL有关。相反,OCP的血清水平可能与导致端粒缩短的氧化应激和全身性炎症有关。55至-15.51%)。结构中氯含量高的非二恶英类PCB(PCB 28和52除外)和类二恶英PCB的暴露与更长的TL有关。相反,OCP的血清水平可能与导致端粒缩短的氧化应激和全身性炎症有关。
更新日期:2020-04-20
down
wechat
bug