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Bioactive ent-isopimarane diterpenoids from Euphorbia neriifolia
Phytochemistry ( IF 3.2 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.phytochem.2020.112373 Jian-Chun Li 1 , Wei-Feng Dai 1 , Dan Liu 1 , Ming-Yan Jiang 1 , Zhi-Jun Zhang 1 , Xuan-Qin Chen 1 , Chin-Ho Chen 2 , Rong-Tao Li 1 , Hong-Mei Li 1
Phytochemistry ( IF 3.2 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.phytochem.2020.112373 Jian-Chun Li 1 , Wei-Feng Dai 1 , Dan Liu 1 , Ming-Yan Jiang 1 , Zhi-Jun Zhang 1 , Xuan-Qin Chen 1 , Chin-Ho Chen 2 , Rong-Tao Li 1 , Hong-Mei Li 1
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Twelve ent-isopimarane diterpenoids, including six undescribed ones, eupnerias J-O, were isolated from the stem barks of Euphorbia neriifolia L. Structurally, eupnerias J-M were the first examples of 18 (or 19)-norditerpenoid with ent-isopimarane skeleton from E. neriifolia. The absolute configuration of eupneria J was established based on the X-ray diffraction analysis and the experimental and calculated electronic circular dichroism (ECD), while the absolute configuration of eupnerias K-N were determined by the experimental and calculated ECD. In addition, the absolute configuration of the known compound, 3β-hydroxysandaracopimaric acid, was determined by comparing its ECD spectrum with eupneria J, and renamed as eupneria P. Furthermore, eupneria J and eurifoloid H showed significant anti-HIV-1 activities with IC50 values of 0.31 and 6.70 μg/mL, respectively, and ent-isopimara-8(14),15-dien-3β,12β-diol possessed obvious anti-influenza virus activity against A/Puerto Rico/8/1934, with an IC50 at 3.86 μg/mL.
中文翻译：
来自大戟的生物活性异海松二萜类化合物
从 Euphorbia neriifolia L 的茎皮中分离出 12 种 ent-isopimarane 二萜，包括 6 种未描述的 eupnerias JO。从结构上讲，eupnerias JM 是 Eupnerias folia folia 中具有 ent-isopimarane 骨架的 18（或 19）-norditerpenoid 的第一个例子。 . 基于X射线衍射分析和实验计算的电子圆二色性（ECD）建立了euneria J的绝对构型，而Eupnerias KN的绝对构型由实验和计算的ECD确定。此外，已知化合物 3β-羟基山梨海松酸的绝对构型是通过将其 ECD 谱与 Eupneria J 进行比较来确定的，并将其重命名为 Eupneria P。此外，Eupneria J 和 eurifolio H 显示出显着的抗 HIV-1 活性，IC50 0.31 和 6.70 μg/mL 的值，
更新日期：2020-07-01
中文翻译：
来自大戟的生物活性异海松二萜类化合物
从 Euphorbia neriifolia L 的茎皮中分离出 12 种 ent-isopimarane 二萜，包括 6 种未描述的 eupnerias JO。从结构上讲，eupnerias JM 是 Eupnerias folia folia 中具有 ent-isopimarane 骨架的 18（或 19）-norditerpenoid 的第一个例子。 . 基于X射线衍射分析和实验计算的电子圆二色性（ECD）建立了euneria J的绝对构型，而Eupnerias KN的绝对构型由实验和计算的ECD确定。此外，已知化合物 3β-羟基山梨海松酸的绝对构型是通过将其 ECD 谱与 Eupneria J 进行比较来确定的，并将其重命名为 Eupneria P。此外，Eupneria J 和 eurifolio H 显示出显着的抗 HIV-1 活性，IC50 0.31 和 6.70 μg/mL 的值，
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