Experimental research into malaria biology and pathogenesis has historically focused on two model systems, in vitro culture of the human parasite Plasmodium falciparum and in vivo infections of laboratory animals using rodent parasites. While there is clear value in having a manipulatable animal model for studying malaria, there have occasionally been controversies around how representative the rodent model is of the human disease, and therefore significant emphasis has been placed on the similarities between the two biological systems. By focusing on basic nuclear functions, we wish to highlight that identifying key differences in the parasites and their interactions with their mammalian hosts can be equally informative and provide remarkable insights into the biology and evolution of these important infectious organisms.

中文翻译：

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Vive laDifférence：利用啮齿动物和人类疟疾之间的差异。

疟疾生物学和发病机理的实验研究历史上一直集中在两个模型系统上，即人类寄生虫恶性疟原虫的体外培养和使用啮齿动物寄生虫的实验动物的体内感染。尽管拥有可操纵的动物模型来研究疟疾具有明显的价值，但关于啮齿类动物模型对人类疾病的代表性有争议，因此有时会引起争议，因此，人们非常重视这两个生物系统之间的相似性。通过关注基本的核功能，我们希望强调指出，鉴定寄生虫的关键差异及其与哺乳动物宿主的相互作用可以提供同等的信息，并为这些重要传染性生物的生物学和进化提供出色的见解。