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Treating juvenile idiopathic arthritis to target: what is the optimal target definition to reach all goals?
Pediatric Rheumatology ( IF 2.8 ) Pub Date : 2020-04-16 , DOI: 10.1186/s12969-020-00428-7
Casper G Schoemaker 1, 2, 3 , Joost F Swart 1, 2 , Nico M Wulffraat 1, 2
Affiliation  

In 2018, an international Task Force formulated recommendations for treating Juvenile Idiopathic Arthritis (JIA) to target. The Task Force has not yet resolved three issues. The first issue is the lack of a single "best" target. The Task Force decided not to recommend the use of a specific instrument to assess inactive disease or remission. Recent studies underscore the use of a broad target definition. The second issue is the basic assumption that a treatment aggressively aimed at the target will have 'domino effects' on other treatment goals as well. Thus far, this assumption was not confirmed for pain, fatigue and stiffness. The third issue is shared decision-making, and the role of individual patient targets. Nowadays, patients and parents should have a more active role in choosing targets and their personal treatment goals. In our department the electronic medical records have been restructured in such a way that the patient's personal treatment goals with a target date appears on the front page. The visualization of their specific personal goals helps us to have meaningful discussions on the individualized treatment strategy and to share decisions. In conclusion, a joint treat to target (T2T) strategy is a promising approach for JIA. The Task Force formulated valuable overarching principles and a first version of recommendations. However, implementation of T2T needs to capture more than just inactive disease. Patients and parents should have an active role in choosing personal targets as well.

中文翻译:

治疗目标性幼年特发性关节炎:达到所有目标的最佳目标定义是什么?

2018年,一个国际工作队制定了针对青少年特发性关节炎(JIA)的治疗建议。工作队尚未解决三个问题。第一个问题是缺乏单一的“最佳”目标。工作队决定不建议使用特定的仪器来评估非活动性疾病或缓解。最近的研究强调使用广泛的目标定义。第二个问题是一个基本假设,即积极针对目标的治疗也会对其他治疗目标产生“多米诺骨牌效应”。到目前为止,这一假设尚未得到证实,其原因包括疼痛,疲劳和僵硬。第三个问题是共同的决策制定,以及各个患者目标的作用。如今,患者和父母应该在选择目标和个人治疗目标方面发挥更积极的作用。在我们的部门中,电子病历已经进行了重组,以使患者的个人治疗目标以及目标日期显示在首页上。他们特定个人目标的可视化有助于我们就个性化治疗策略进行有意义的讨论并分享决策。总之,针对JIA的联合治疗(T2T)策略是一种有前途的方法。工作队制定了宝贵的总体原则和建议的第一版。但是,实施T2T不仅需要捕获非活动性疾病。患者和父母在选择个人目标时也应发挥积极作用。带有目标日期的个人治疗目标显示在首页上。他们特定个人目标的可视化有助于我们就个性化治疗策略进行有意义的讨论并分享决策。总之,联合靶向治疗(T2T)策略是JIA的一种有前途的方法。工作队制定了宝贵的总体原则和建议的第一版。但是,实施T2T不仅需要捕获非活动性疾病。患者和父母在选择个人目标时也应发挥积极作用。带有目标日期的个人治疗目标显示在首页上。他们特定个人目标的可视化有助于我们就个性化治疗策略进行有意义的讨论并分享决策。总之,联合靶向治疗(T2T)策略是JIA的一种有前途的方法。工作队制定了宝贵的总体原则和建议的第一版。但是,实施T2T不仅需要捕获非活动性疾病。患者和父母在选择个人目标时也应发挥积极作用。工作队制定了宝贵的总体原则和建议的第一版。但是,实施T2T不仅需要捕获非活动性疾病。患者和父母在选择个人目标时也应发挥积极作用。工作队制定了宝贵的总体原则和建议的第一版。但是,实施T2T不仅需要捕获非活动性疾病。患者和父母在选择个人目标时也应发挥积极作用。
更新日期:2020-04-22
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