BACKGROUND Tumor recurrence in patients after surgery severely reduces the survival rate of surgical patients. Targeting and killing recurrent tumor cells and tissues is extremely important for the cancer treatment. RESULTS Herein, we designed a nano-biomimetic photothermal-controlled drug-loading platform HepM-TSL with good targeting ability and immunocompatibility for the treatment of recurrent hepatocellular carcinoma. HepM-TSL can accurately target the recurrent tumor area with the aid of the cloaked homotypic cell membrane and release the chemotherapy drugs in a controlled manner. In vivo results have confirmed that HepM-TSL loaded with drugs and photosensitizer achieves the synergistic treatment of recurrent hepatocellular carcinoma with good therapeutic effect and slight side effects. CONCLUSION Accordingly, HepM-TSL provides a sound photothermal-chemotherapy synergistic strategy for the treatment of other recurrent cancers besides of recurrent hepatocellular carcinoma.

中文翻译：

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同型细胞膜包裹仿生纳米载体，用于精确光热化疗治疗复发性肝细胞癌。


背景技术患者术后肿瘤复发严重降低了手术患者的生存率。靶向并杀死复发的肿瘤细胞和组织对于癌症治疗极其重要。结果我们设计了一种具有良好靶向能力和免疫相容性的纳米仿生光热控制载药平台HepM-TSL，用于治疗复发性肝细胞癌。 HepM-TSL借助隐匿的同型细胞膜，能够精准靶向复发肿瘤区域，可控地释放化疗药物。体内实验结果证实HepM-TSL负载药物和光敏剂实现了对复发性肝细胞癌的协同治疗，治疗效果好，副作用小。结论 因此，HepM-TSL为治疗复发性肝细胞癌以外的其他复发性癌症提供了良好的光热化疗协同策略。