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The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats
BMC Neuroscience ( IF 2.4 ) Pub Date : 2020-04-16 , DOI: 10.1186/s12868-020-00564-6
Tao Zhang 1 , Jiahui Niu 2 , Yaxian Wang 2 , Junying Yan 3 , Wen Hu 2, 4 , Daguo Mi 5
Affiliation  

Background Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves in regulating vasomotor activities is comprehensively studied and well recognized, that of sensory nerves is underappreciated. Studies in rodents have shown that severance of the sciatic nerve leads to vasodilatation in the foot, but whether sympathetic or sensory nerve fibers or both are responsible for the neurogenic vasodilatation remains unknown. Results In adult Sprague–Dawley rats, vasodilatation after transection of the sciatic nerve gradually diminished to normal within 3–4 days. The neurotmesis-induced neurogenic vasodilatation was not detectable when the sciatic nerve was chronically deafferentated by selective resection of the dorsal root ganglia (DRGs) that supply the nerve. Specific activation of C-afferents by intra-neural injection of capsaicin resulted in neurogenic vasodilatation to a magnitude comparable to that by neurotmesis, and transection of the sciatic nerve pre-injected with capsaicin did not induce further vasodilatation. Conclusions Our results collectively indicate that vasodilatation after traumatic nerve injury in rats is predominantly mediated by C-fiber afferents.

中文翻译:

C-传入在介导大鼠急性坐骨神经损伤后足底皮肤神经源性血管舒张中的作用

背景皮肤血管的血管舒缩调节对皮肤温度调节控制的功能至关重要,涉及神经和非神经机制。尽管交感神经在调节血管舒缩活动中的作用得到了全面的研究和认可,但感觉神经的作用却没有得到充分的认识。对啮齿动物的研究表明,坐骨神经的切断导致足部血管舒张,但交感神经或感觉神经纤维或两者是否导致神经源性血管舒张仍然未知。结果 在成年 Sprague-Dawley 大鼠中,坐骨神经横断后的血管舒张在 3-4 天内逐渐减少至正常。当通过选择性切除供应神经的背根神经节 (DRG) 使坐骨神经长期去传入神经时,无法检测到神经损伤引起的神经源性血管舒张。通过神经内注射辣椒素特异性激活 C 传入神经,导致神经源性血管舒张达到与神经损伤相当的程度,并且预先注射辣椒素的坐骨神经的横断不会引起进一步的血管舒张。结论我们的结果共同表明,大鼠创伤性神经损伤后的血管舒张主要由 C 纤维传入介导。预先注射辣椒素的坐骨神经的横断不会引起进一步的血管舒张。结论我们的结果共同表明,大鼠创伤性神经损伤后的血管舒张主要由 C 纤维传入介导。预先注射辣椒素的坐骨神经的横断不会引起进一步的血管舒张。结论我们的结果共同表明,大鼠创伤性神经损伤后的血管舒张主要由 C 纤维传入介导。
更新日期:2020-04-16
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