Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR-4, PTX-3, Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among hematopoietic stem cell transplant recipients with oncohem,Mycoses

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Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the TLR-4, PTX-3, Dectin-1 (CLEC/A) genes with development of invasive aspergillosis among hematopoietic stem cell transplant recipients with oncohem
Mycoses ( IF 4.1 ) Pub Date : 2020-06-09 , DOI: 10.1111/myc.13087
Ayse Kalkanci ₁ , Esra Tug ₂ , Isil Fidan ₁ , Ozlem Guzel Tunccan ₃ , Zubeyde Nur Ozkurt ₄ , Zeynep Arzu Yegin ₄ , Elif Ayça Sahin _{1,

5} , Zeynep Kuralay _{1,

6}

Affiliation

Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll‐like receptors (TLRs), dendritic cell‐associated C‐type lectin‐1 (Dectin‐1/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by Candida and Aspergillus. We screened TLR4, Dectin‐1 and PTX3 polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.

中文翻译：

回顾性分析 TLR-4、PTX-3、Dectin-1 (CLEC/A) 基因的表达和单核苷酸多态性 (SNP) 与患有癌瘤的造血干细胞移植受者发生侵袭性曲霉病的相关性

多项研究描述了侵袭性真菌感染患者模式识别受体 (PRR) 的单核苷酸多态性 (SNP)，例如 Toll 样受体 (TLR)、树突状细胞相关 C 型凝集素-1 (Dectin-1/CLEC7A) 基因(IFIs) 由念珠菌和曲霉菌引起。我们在患有侵袭性曲霉病 (IA) 基础血液系统恶性肿瘤的土耳其人群中筛选了 TLR4、Dectin-1 和 PTX3 多态性。

更新日期：2020-06-09

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