A gene signature for immune subtyping of desert, excluded, and inflamed ovarian tumors.,American Journal of Reproductive Immunology

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A gene signature for immune subtyping of desert, excluded, and inflamed ovarian tumors.
American Journal of Reproductive Immunology ( IF 2.5 ) Pub Date : 2020-04-15 , DOI: 10.1111/aji.13244
Agata Mlynska ₁ , Ramunė Vaišnorė ₂ , Vytautas Rafanavičius ₃ , Simonas Jocys ₂ , Julija Janeiko ₂ , Monika Petrauskytė ₂ , Simas Bijeikis ₂ , Piotras Cimmperman ₂ , Birutė Intaitė ₁ , Karolina Žilionytė ₁ , Aušrinė Barakauskienė _{3,

4} , Raimundas Meškauskas ₅ , Emilija Paberalė ₁ , Vita Pašukonienė ₁

Affiliation

The current tumor immunology paradigm emphasizes the role of the immune tumor microenvironment and distinguishes several histologically and transcriptionally different immune tumor subtypes. However, the experimental validation of such classification is so far limited to selected cancer types. Here, we aimed to explore the existence of inflamed, excluded, and desert immune subtypes in ovarian cancer, as well as investigate their association with the disease outcome.

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